Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy
Autor: | Jingjing Wang, Jie Liu, Bing Sun, Li Li, Luyao Sun, Zhi Ping Xu |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Pharmaceutical Science
Medicine (miscellaneous) Apoptosis 02 engineering and technology 01 natural sciences Applied Microbiology and Biotechnology Nanocomposites Homologous targeting Mice Drug Delivery Systems Biomimetics Neoplasms Hydroxides Cytotoxicity Mice Inbred BALB C Chemistry 021001 nanoscience & nanotechnology 3. Good health Molecular Medicine Female Biomimetic 0210 nano-technology Biotechnology Hyperthermia Biomedical Engineering Bioengineering Antineoplastic Agents 010402 general chemistry Photo-chemotherapy Immune system In vivo colorectal carcinoma Cell Line Tumor medicine Medical technology Animals Humans R855-855.5 Immune escape Research Cancer Hyperthermia Induced Photothermal therapy Phototherapy medicine.disease 0104 chemical sciences Drug Liberation HEK293 Cells Tumor progression Cancer cell Cancer research Tumor Escape Layered double hydroxide nanosheets TP248.13-248.65 |
Zdroj: | Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-16 (2021) Journal of Nanobiotechnology |
ISSN: | 1477-3155 |
Popis: | Background Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges. Hypothetically, cancer cell membrane (CCM) can homologously target the tumor whereas multi-modal therapy can complement the disadvantages of singular therapies. Meanwhile, moderate hyperthermia induced by photothermal therapy can boost the cellular uptake of therapeutic agents by cancer cells. Results CCM-cloaked indocyanine green (ICG)-incorporated and abraxane (PTX-BSA)-loaded layered double hydroxide (LDH) nanosheets (LIPC NSs) were fabricated for target efficient photo-chemotherapy of colorectal carcinoma (CRC). The CCM-cloaked LDH delivery system showed efficient homologous targeting and cytotoxicity, which was further enhanced under laser irradiation to synergize CRC apoptosis. On the other hand, CCM-cloaking remarkably reduced the uptake of LDH NSs by HEK 293T cells and macrophages, implying mitigation of the side effects and the immune clearance, respectively. In vivo data further exhibited that LIPC NSs enhanced the drug accumulation in tumor tissues and significantly retarded tumor progression under laser irradiation at very low therapeutic doses (1.2 and 0.6 mg/kg of ICG and PTX-BSA), without observed side effects on other organs. Conclusions This research has demonstrated that targeting delivery efficiency and immune-escaping ability of LIPC NSs are tremendously enhanced by CCM cloaking for efficient tumor accumulation and in situ generated hyperthermia boosts the uptake of LIPC NSs by cancer cells, a potential effective way to improve the multi-modal cancer therapy. Graphical Abstract |
Databáze: | OpenAIRE |
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