Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

Autor: Jingjing Wang, Jie Liu, Bing Sun, Li Li, Luyao Sun, Zhi Ping Xu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Pharmaceutical Science
Medicine (miscellaneous)
Apoptosis
02 engineering and technology
01 natural sciences
Applied Microbiology and Biotechnology
Nanocomposites
Homologous targeting
Mice
Drug Delivery Systems
Biomimetics
Neoplasms
Hydroxides
Cytotoxicity
Mice
Inbred BALB C
Chemistry
021001 nanoscience & nanotechnology
3. Good health
Molecular Medicine
Female
Biomimetic
0210 nano-technology
Biotechnology
Hyperthermia
Biomedical Engineering
Bioengineering
Antineoplastic Agents
010402 general chemistry
Photo-chemotherapy
Immune system
In vivo
colorectal carcinoma
Cell Line
Tumor
medicine
Medical technology
Animals
Humans
R855-855.5
Immune escape
Research
Cancer
Hyperthermia
Induced
Photothermal therapy
Phototherapy
medicine.disease
0104 chemical sciences
Drug Liberation
HEK293 Cells
Tumor progression
Cancer cell
Cancer research
Tumor Escape
Layered double hydroxide nanosheets
TP248.13-248.65
Zdroj: Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-16 (2021)
Journal of Nanobiotechnology
ISSN: 1477-3155
Popis: Background Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges. Hypothetically, cancer cell membrane (CCM) can homologously target the tumor whereas multi-modal therapy can complement the disadvantages of singular therapies. Meanwhile, moderate hyperthermia induced by photothermal therapy can boost the cellular uptake of therapeutic agents by cancer cells. Results CCM-cloaked indocyanine green (ICG)-incorporated and abraxane (PTX-BSA)-loaded layered double hydroxide (LDH) nanosheets (LIPC NSs) were fabricated for target efficient photo-chemotherapy of colorectal carcinoma (CRC). The CCM-cloaked LDH delivery system showed efficient homologous targeting and cytotoxicity, which was further enhanced under laser irradiation to synergize CRC apoptosis. On the other hand, CCM-cloaking remarkably reduced the uptake of LDH NSs by HEK 293T cells and macrophages, implying mitigation of the side effects and the immune clearance, respectively. In vivo data further exhibited that LIPC NSs enhanced the drug accumulation in tumor tissues and significantly retarded tumor progression under laser irradiation at very low therapeutic doses (1.2 and 0.6 mg/kg of ICG and PTX-BSA), without observed side effects on other organs. Conclusions This research has demonstrated that targeting delivery efficiency and immune-escaping ability of LIPC NSs are tremendously enhanced by CCM cloaking for efficient tumor accumulation and in situ generated hyperthermia boosts the uptake of LIPC NSs by cancer cells, a potential effective way to improve the multi-modal cancer therapy. Graphical Abstract
Databáze: OpenAIRE
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