Necrotizing and haemorrhagic hepatitis and enteritis in commercial layer pullets
| Autor: | Yuko Sato, Patricia S. Wakenell, Eric Gingerich, Tsang Long Lin, William L. Wigle |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Indiana medicine.medical_specialty Pathology 040301 veterinary sciences Salmonella enteritidis Hemorrhage Hepatitis Animal Newcastle disease Gastroenterology Enteritis 0403 veterinary science Necrosis 03 medical and health sciences Immune system Food Animals Internal medicine medicine Animals Poultry Diseases Hepatitis General Immunology and Microbiology biology business.industry Amyloidosis Vaccination 04 agricultural and veterinary sciences medicine.disease biology.organism_classification 030104 developmental biology Liver Female Animal Science and Zoology Flock business Chickens |
| Zdroj: | Avian Pathology. 46:84-89 |
| ISSN: | 1465-3338 0307-9457 |
| Popis: | This case report describes an episode of recurring severe necrotizing and haemorrhagic hepatitis and enteritis experienced in a flock of commercial layer pullets at 12 weeks of age and again at 18 weeks of age in Indiana. Pullets had been vaccinated at 10 weeks old using a trivalent Salmonella Enteritidis (SE)/Newcastle disease/infectious bronchitis oil-emulsion-inactivated vaccine. The pullets were found dead at 12 weeks with firm but friable, enlarged, haemorrhagic livers, enlarged spleens, and necrohaemorrhagic intestines. Histopathologic findings were consistent with a necrotizing and haemorrhagic enteritis and hepatitis. Livers had multiple intra-sinusoidal thrombi, intestines contained Gram-positive bacterial colonies, and spleens had marked lymphoid depletion. The pullets seemed to improve after antibiotic treatment. Pullets were vaccinated with an inactivated SE vaccine at 14 weeks of age. A second spike of mortality occurred at 18 weeks of age. Although clostridial enteritis and hepatitis were highly suspected in the two cases based on macroscopic and microscopic findings, no significant bacterial or viral agents were isolated from the livers and intestines. In summary, lesions in the liver and intestines are speculated to be due to repetitive vaccination, leading to an anamnestic response by the immune system, and resulting in an immune-mediated response. However, much of the pathogenesis is still unclear, and other causes such as unidentified infectious aetiology, transmissible amyloidosis, and hypersensitivity may need further investigation. |
| Databáze: | OpenAIRE |
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