Epidemiologic and Metabolic Studies of a Goiter Endemic in Eastern Kentucky
| Autor: | A. I. Pressman, R. L. Vought, W. T. London, D. A. Koutras |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
endocrine system
medicine.medical_specialty Goiter endocrine system diseases Epidemiology Endocrinology Diabetes and Metabolism Clinical Biochemistry Population Prevalence Kentucky chemistry.chemical_element Thyroid Function Tests Urine Iodine Biochemistry Excretion Feces Endocrinology Water Supply Internal medicine Humans Medicine Fluids and Secretions education education.field_of_study business.industry Biochemistry (medical) Thyroid medicine.disease Iodine deficiency Body Fluids Metabolism medicine.anatomical_structure chemistry Thyroid function business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 25:1091-1100 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | In a small community located in an endemic goiter area in Eastern Kentucky, 33.1% of the entire population was found to have enlarged thyroid glands. Below the age of 40 there was no difference in the goiter prevalence rates of the sexes. Dietary iodine deficiency of the population as determined by iodide blood levels, estimated daily urinary iodine excretion, and dietary iodine intake, was not demonstrated as a primary factor. The most striking difference between goitrous and nongoitrous individuals living in the same community was an increased absolute iodine uptake (AIU, μg/hr) in those persons with thyroid enlargement. The elevated AIU's were accompanied by normal PBI concentrations in the serum, suggesting an intrathyroidal metabolic defect in iodine utilization or positive iodine balance with storing of iodine in the thyroid. Genetic and environmental factors were also investigated. The geographic distribution of households with goitrous persons was random, but the distribution of goiter within hous... |
| Databáze: | OpenAIRE |
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