Glutamate decarboxylase antibody levels predict rate of β-cell decline in adult-onset diabetes
| Autor: | Anders Gottsäter, Mona Landin-Olsson, P. Fernlund, W. A. Hagopian, G. Sundkvist, Åke Lernmark |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Glutamate decarboxylase Glucagon Statistics Nonparametric Islets of Langerhans Endocrinology Predictive Value of Tests Immunopathology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Aged Autoantibodies Glycated Hemoglobin Analysis of Variance Chi-Square Distribution Glutamate Decarboxylase business.industry Autoantibody General Medicine Middle Aged medicine.disease Recombinant Proteins Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Predictive value of tests Analysis of variance business Chi-squared distribution Biomarkers |
| Zdroj: | Diabetes Research and Clinical Practice. 27:133-140 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/0168-8227(95)01026-a |
| Popis: | Glutamate decarboxylase autoantibodies (GAD65Ab) and beta-cell function were evaluated at and 3 years after diabetes onset in consecutive subjects over 15 years of age. At onset, 21/32 (66%) insulin-treated patients (mean age 43, range 16-79 years) had GAD65Ab; all GAD65Ab persisted 3 years later. At onset, 20/82 (24%) non-insulin-treated patients (mean age 56, range 20-79 years) had GAD65Ab. Of those with persistent GAD65Ab, 8 non-insulin-treated and 11 insulin-treated patients consented to follow-up glucose and glucagon stimulation tests. For non-insulin-treated patients, quantitative GAD65Ab index at onset correlated inversely with 1 + 3 min C-peptide response to glucose (r = -0.68, P0.05) and to glucagon (r = -0.79, P0.05) 3 years later. Those with high (0.50) initial GAD65Ab index had lower C-peptide (fasting, 1 + 3 min after glucose and after glucagon) 3 years later, versus those with low (0.50) initial GAD65Ab index (P0.05). In conclusion, not only did GAD65Ab presence predict future insulin dependence, but higher GAD65Ab levels may mark more rapid decline in beta-cell function in apparent non-insulin-dependent diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect