Number of circulating CD14-positive cells and the serum levels of TNF-α are raised in acute charcot foot
| Autor: | Afsie Sabokbar, Michael Edmonds, N L Petrova, Guillaume Mabilleau |
|---|---|
| Přispěvatelé: | Groupe d'Études Remodelage Osseux et bioMatériaux (GEROM), Université d'Angers (UA) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Diabetes Care Electronic Pages Endocrinology Diabetes and Metabolism CD14 [SDV]Life Sciences [q-bio] Lipopolysaccharide Receptors Arthropathy Neurogenic 030209 endocrinology & metabolism Bone resorption Monocytes 03 medical and health sciences 0302 clinical medicine Multinucleate Osteoclast Diabetes mellitus Internal Medicine medicine Humans Online Letters: Observations Antigens Receptor ComputingMilieux_MISCELLANEOUS 030304 developmental biology Advanced and Specialized Nursing 0303 health sciences biology business.industry Tumor Necrosis Factor-alpha medicine.disease 3. Good health medicine.anatomical_structure RANKL Immunology biology.protein Tumor necrosis factor alpha Arthropathy Neurogenic business |
| Zdroj: | Diabetes Care Diabetes Care, American Diabetes Association, 2011, 34, pp.e33. ⟨10.2337/dc10-1695⟩ |
| ISSN: | 0149-5992 |
| DOI: | 10.2337/dc10-1695⟩ |
| Popis: | Charcot neuro-osteoarthropathy (CNO) is a devastating complication of diabetes characterized by increased local bone resorption mediated by osteoclasts. Often CNO leads to multiple fractures and joint destruction resulting in severe deformity of the foot. Osteoclasts are multinucleated cells that have a common precursor with monocytes/macrophages (1). Previously, we reported that the number of osteoclasts generated in vitro from circulating cells was higher in acute CNO patients compared with diabetic control subjects and was partially independent from receptor activator for NF-κB (RANK)-RANK ligand (RANKL), the main osteoclastogenic mediator (2). One hypothesis could be that the number of circulating osteoclast precursors is increased in CNO. Among all monocytes subpopulations, CD14-positive cells are the most potent to transform into bone-resorbing osteoclasts (3). We studied 11 diabetic patients with recent onset of acute CNO, 10 diabetic … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|