Prevalence and risk factors of bone metastasis and skeletal related events in patients with primary breast cancer in Japan
Autor: | Yasuo Matsutani, Masakazu Toi, Ryuji Okamura, Shiro Imai, Takashi Hashimoto, Akira Yamauchi, Eiji Nakatani, Hirofumi Suwa, You Ichinose, Shigeru Tsuyuki, Hironori Kato, Hiroshi Yoshibayashi, Norimichi Kan, Shunichi Higashide, Fumie Tanaka, Yoshio Moriguchi, Takashi Inamoto, Takashi Okino, Masahiro Takada, Tomika Harada, Ichiro Nakayama, Shingo Sakata, Hiroyasu Yamashiro, Yasuo Wada, Kazuhiko Yamagami |
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Rok vydání: | 2013 |
Předmět: |
Adult
Oncology medicine.medical_specialty Skeletal related events Bone Neoplasms Breast Neoplasms Kaplan-Meier Estimate Breast cancer Japan Quality of life Risk Factors Surgical oncology Internal medicine medicine Humans In patient Muscle Skeletal Aged Aged 80 and over Bone Density Conservation Agents business.industry Incidence (epidemiology) Bone metastasis Hematology General Medicine Middle Aged medicine.disease Lymphatic Metastasis Quality of Life Female Surgery Neoplasm Recurrence Local Primary breast cancer business |
Zdroj: | International Journal of Clinical Oncology. 19:852-862 |
ISSN: | 1437-7772 1341-9625 2003-2005 |
Popis: | Bone metastasis (BM) is important for studying systemic spread of breast cancer. It often causes skeletal-related events (SREs) that worsen quality of life. We investigated the prevalence and risk factors for BM and SRE using a dataset from the Breast Oncology Research Network (BORN) in Japan.We collected data on primary breast cancer patients with node-positive or node-negative disease at intermediate to high risk of recurrence. The risk factors affecting the BM-free rate, SRE-free rate and overall survival were analyzed by using the Cox proportional hazard model.Data of 1,779 patients who were diagnosed with breast cancer during 2003-2005 were collected from the BORN and 1,708 cases were used for analysis. The median follow-up duration was 5.71 years. BM developed in 193 cases (11.3 %) and the BM-free rate at 5 years was 89.2 %. The annual hazard ratio of BM development differs remarkably according to the tumor subtype. SREs occurred in 133 (68.9 %) out of 193 patients and the SRE-free rate at 5 years was 92.6 %. In the multivariate analysis, clinical stage (P0.0001), number of lymph node (LN) metastases (P = 0.0029), tumor subtype (P = 0.034) and progesterone receptor status (P = 0.038) were independently significant risk factors for BM-free rate, but only clinical stage (P0.0001) and number of LN metastases (P = 0.0004) significantly correlated with SRE-free rate.This retrospective study clarifies the prevalence and risk factors for BM and SRE in Japanese breast cancer patients. Our results show the importance of considering subtype in the care of BM and SRE. |
Databáze: | OpenAIRE |
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