Modelling and Measuring Redox Cycling and Cytotoxicity of Quinones
| Autor: | Louise M. Hughes, Jordana K. Wingate, Renate Griffith, R. John Aitken |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Alkylation
Chemistry Biochemistry (medical) Clinical Biochemistry Quinones Pharmaceutical Science Models Biological Cell Line Quinone Redox Activity Molecular Weight Mice Structure-Activity Relationship Toxicity Tests Toxicity Animals Organic chemistry Pharmacology (medical) Sulfhydryl Compounds Cytotoxicity Oxidation-Reduction Redox cycling |
| Zdroj: | Drug Metabolism Letters. 1:245-253 |
| ISSN: | 1872-3128 |
| DOI: | 10.2174/187231207783221457 |
| Popis: | The roles of alkylation and redox cycling in quinone toxicity were investigated. In general the more cytotoxic quinones produced the highest responses in an assay monitoring redox activity. No evidence of alkylation of high molecular weight protein thiols was detected. We conclude quinone toxicity is dominated by redox cycling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|