Diffusion tensor imaging in horizontal gaze palsywith progressive scoliosis
| Autor: | V. Ilayaraja, S. Rajasekaran, Ajoy Prasad Shetty, Ashwin Avadhani |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Decussation medicine.medical_specialty Adolescent Biomedical Engineering Biophysics Corpus callosum Nerve Fibers Myelinated Ocular Motility Disorders Middle cerebellar peduncle Humans Medicine Radiology Nuclear Medicine and imaging business.industry Brain Horizontal gaze palsy Anatomy medicine.disease Surgery Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Scoliosis Brainstem medicine.symptom business Tractography Diffusion MRI |
| Zdroj: | Magnetic Resonance Imaging. 28:212-216 |
| ISSN: | 0730-725X |
| DOI: | 10.1016/j.mri.2009.10.004 |
| Popis: | Horizontal gaze palsy with progressive scoliosis (HGPPS) is a rare disorder characterized by absence of conjugate horizontal eye movements, preservation of vertical gaze and convergence, progressive scoliosis developing in childhood and adolescence. It is caused by mutations in the ROBO3 gene which are critical for the crossing of long ascending medial lemniscal and descending corticospinal tracts in the medulla. Diffusion tensor imaging on a 14-year-old boy with HGPPS revealed ipsilateral ascending and descending connectivity in the brainstem without any crossing over of the major tracts although normal interhemispheric connections in the corpus callosum was demonstrable. Absent decussation of smaller sized superior cerebellar peduncles but with normal crossing over of the middle cerebellar peduncle was also observed. Tractography is a valuable investigative modality to assess neuronal connections in the brain and is a useful adjunct to the structural magnetic resonance imaging in confirming the diagnosis of HGPPS. |
| Databáze: | OpenAIRE |
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