Increased bioavailability of hesperetin-7-glucoside compared with hesperidin results in more efficient prevention of bone loss in adult ovariectomised rats
| Autor: | Christine Morand, Marie Jeanne Davicco, Angel Gil-Izquierdo, Vronique Habauzit, Inge Lise F. Nielsen, Véronique Coxam, Anna Trzeciakiewicz, Elizabeth A. Offord, Gary Williamson, Patrice Lebecque, Winnie S.S. Chee, Denis Barron, Marie Noelle Horcajada |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Bone density Ovariectomy Drug Evaluation Preclinical Biological Availability Medicine (miscellaneous) Weight Gain Excretion chemistry.chemical_compound Hesperidin Bone Density Internal medicine medicine Animals Femur Rats Wistar Orange juice Bone mineral Nutrition and Dietetics Uterus Hesperidina Hesperetin Organ Size Rats Bioavailability Endocrinology chemistry Dietary Supplements Osteoporosis Female Bone Remodeling |
| Popis: | Hesperidin (Hp), a citrus flavonoid predominantly found in oranges, shows bone-sparing effects in ovariectomised (OVX) animals. In human subjects, the bioavailability of Hp can be improved by the removal of the rhamnose group to yield hesperetin-7-glucoside (H-7-glc). The aim of the present work was to test whether H-7-glc was more bioavailable and therefore more effective than Hp in the prevention of bone loss in the OVX rat. Adult 6-month-old female Wistar rats were sham operated or OVX, then pair fed for 90 d a casein-based diet supplemented or not with freeze-dried orange juice enriched with Hp or H-7-glc at two dose equivalents of the hesperetin aglycone (0·25 and 0·5 %). In the rats fed 0·5 %, a reduction in OVX-induced bone loss was observed regarding total bone mineral density (BMD):+7·0 % in OVX rats treated with Hp (HpOVX) and +6·6 % in OVX rats treated with H-7-glc (H-7-glcOVX)v.OVX controls (P v.the OVX controls (P v.Hp groups, and the metabolite profile showed the absence of eriodictyol metabolites and increased levels of hesperetin sulphates. Taken together, improved bioavailability of H-7-glc may explain the more efficient bone protection of this compound. |
| Databáze: | OpenAIRE |
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