Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss

Autor: Mireille J. Serlie, Mariëtte T. Ackermans, Jan Booij, Ignace M. C. Janssen, Esther M. van der Zwaal, Barbara A. de Weijer, Frits J. Berends, Eric Fliers, Elsmarieke van de Giessen, Arnold van de Laar, Susanne E. la Fleur
Přispěvatelé: AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Intensive Care Medicine, Radiology and Nuclear Medicine, Other Research, Laboratory for Endocrinology, Endocrinology, ANS - Cellular & Molecular Mechanisms, Nuclear Medicine
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
Blood Glucose
Leptin
medicine.medical_specialty
Pyrrolidines
Time Factors
medicine.medical_treatment
Gastric Bypass
030209 endocrinology & metabolism
medicine.disease_cause
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Weight loss
Internal medicine
Weight Loss
medicine
Humans
Pharmacology (medical)
Biological Psychiatry
Tomography
Emission-Computed
Single-Photon
Pharmacology
Receptors
Dopamine D2
Gastric bypass surgery
Insulin
Receptors
Dopamine D3
Feeding Behavior
medicine.disease
Obesity
Corpus Striatum
Ghrelin
Obesity
Morbid
Psychiatry and Mental health
Treatment Outcome
Endocrinology
Neurology
Food craving
Benzamides
Female
Neurology (clinical)
Radiopharmaceuticals
medicine.symptom
Psychology
Body mass index
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: European neuropsychopharmacology, 26(7), 1190-1200. Elsevier
ISSN: 0924-977X
Popis: In several studies reduced striatal dopamine D2/3 receptor (D2/3R) availability was reported in obese subjects compared to lean controls. Whether this is a reversible phenomenon remained uncertain. We previously determined the short-term effect of Roux-en-Y gastric bypass surgery (RYGB) on striatal D2/3R availability (using [(123)I]IBZM SPECT) in 20 morbidly obese women. Striatal D2/3R availability was lower compared to controls at baseline, and remained unaltered after 6 weeks, despite significant weight loss. To determine whether long-term bariatric surgery-induced weight loss normalizes striatal D2/3R binding, we repeated striatal D2/3R binding measurements at least 2 years after RYGB in 14 subjects of the original cohort. In addition, we assessed long-term changes in body composition, eating behavior and fasting plasma levels of leptin, ghrelin, insulin and glucose. Mean body mass index declined from 46±7kg/m(2) to 32±6kg/m(2), which was accompanied by a significant increase in striatal D2/3R availability (p=0.031). Striatal D2/3R availability remained significantly reduced compared to the age-matched controls (BMI 22±2kg/m(2); p=0.01). Changes in striatal D2/3R availability did not correlate with changes in body weight/fat, insulin sensitivity, ghrelin or leptin levels. Scores on eating behavior questionnaires improved and changes in the General Food Craving Questionnaire-State showed a borderline significant correlation with changes in striatal D2/3R availability. These findings show that striatal D2/3R availability increases after long-term bariatric-surgery induced weight loss, suggesting that reduced D2/3R availability in obesity is a reversible phenomenon.
Databáze: OpenAIRE
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