Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis
| Autor: | Ioannis Τoumpoulis, Evangelos Polymeropoulos, Ioannis Rizos, Efstratios Patsouris, Pantelis G. Bagos, Maria Papadimitriou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pharmaceutical Science macromolecular substances 030204 cardiovascular system & hematology Cochrane Library Placebo Post-operative atrial fibrillation 03 medical and health sciences 0302 clinical medicine Medicine 030212 general & internal medicine Vitamin C General Pharmacology Toxicology and Pharmaceutics CABG Valvular surgery business.industry lcsh:RM1-950 Atrial fibrillation Publication bias Cardiac surgery medicine.disease Clinical trial lcsh:Therapeutics. Pharmacology Anesthesia Meta-analysis cardiovascular system business Research Article |
| Zdroj: | Advanced Pharmaceutical Bulletin, Vol 6, Iss 2, Pp 243-250 (2016) |
| ISSN: | 2251-7308 2228-5881 |
| Popis: | Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery. Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo. Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 – 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found. Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery. |
| Databáze: | OpenAIRE |
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