| Autor: |
Erin M. Edwards, Jeffrey A. Stanley, Ana M. Daugherty, Jonathan Lynn, Michael R. Borich, Nora E. Fritz |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of neuroimaging : official journal of the American Society of NeuroimagingREFERENCES. |
| ISSN: |
1552-6569 |
| Popis: |
Myelin water fraction (MWF) deficits as measured by myelin water imaging (MWI) have been related to worse motor function in persons with multiple sclerosis (PwMS). However, it is unknown if measures from MWI metrics in motor areas relate to fall risk measures in PwMS. The objective of this study was to examine the relationship between MWI measures in motor areas to performance on clinical measures of fall risk and disability in PwMS.Sixteen individuals with relapsing-remitting MS participated (1 male, 15 female; age 47.1 years [12.3]; Expanded Disability Status Scale 4.0 [range 0-6.5]) and completed measures of walking and fall risk (Timed 25 Foot Walk [T25FW] and Timed Up and Go). MWF and the geometric mean of the intra-/extracellular water TThe geomTMWI of key motor regions was associated with walking performance in PwMS. Further MWI studies are needed to identify relationships between pathology and clinical function in PwMS to guide targeted rehabilitation therapies aimed at preventing falls. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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