Resting-state functional network connectivity underlying eating disorder symptoms in healthy young adults
| Autor: | Ximei Chen, Chuan Wang, Qinghua He, Mingyue Xiao, Hong Chen, Tingyong Feng, Yun Tian, Yijun Luo, Jiang Qiu, Xiao Gao, Xu Lei, Jingmin Qin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Anorexia Nervosa Anorexia nervosa ASN Anterior salience network SN Salience network 0302 clinical medicine VSN Visuospatial network SD Standard deviation DMN Default mode network TMS Transcranial magnetic stimulation Default mode network education.field_of_study Reward sensitivity RSN Resting-state network AG Angular gyrus Bulimia nervosa ROI Region of interest 05 social sciences Functional network connectivity SFG Superior frontal gyrus tDCS Transcranial direct current stimulation Regular Article Magnetic Resonance Imaging LECN Left executive control network BGN Basal ganglia network Eating disorders rs-fMRI Resting-state functional magnetic resonance imaging Neurology Self-referential thinking TPN Task-positive network Female BN Bulimia nervosa medicine.symptom Binge-Eating Disorder Clinical psychology IFG Inferior frontal gyrus FD Framewise displacement Adolescent PCUN Precuneus network MOG Middle occipital gyrus Cognitive Neuroscience Population Computer applications to medicine. Medical informatics Resting-state network R858-859.7 MFG Middle frontal gyrus BMI Body mass index 050105 experimental psychology Feeding and Eating Disorders Young Adult 03 medical and health sciences ECN Executive control network FNC Functional network connectivity medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Disordered eating Bulimia Nervosa TNN Task-negative network education Inhibitory control RC346-429 BED Binge-eating disorder VAN Ventral attention network RECN Right executive control network PCC Posterior cingulate cortex Binge eating business.industry AN Anorexia nervosa FC Functional connectivity SMN Sensorimotor network medicine.disease BOLD Blood oxygen level-dependent PSN Posterior salience network Neurology (clinical) Neurology. Diseases of the nervous system DVARS Temporal Derivative of root mean square VARiance over voxelS EDDS Eating disorder diagnosis scale business Eating disorder symptoms PHG Parahippocampal gyrus Body mass index 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage: Clinical, Vol 30, Iss, Pp 102671-(2021) NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| Popis: | Highlights • This study examined the resting-state functional network connectivity underlying eating disorder symptoms in a large sample of healthy young adults (n = 693). • Individuals with higher levels of eating disorder symptoms displayed weaker intra-network connectivity of the executive control network and basal ganglia network, as well as weaker inter-network connectivity in the three examined networks (i.e., the executive control network, basal ganglia network, and default mode network). • The findings suggest that these neural circuits may play a key role in symptoms of disordered eating in healthy adults. They further reveal that the less efficient information exchange within and between intrinsic networks associated with self-referential thinking, inhibitory control, and reward sensitivity are strongly related to eating disorder symptoms. Previous neuroimaging research of eating disorders such as anorexia nervosa and bulimia nervosa has mainly focused on clinical patients, indicating the crucial role of intrinsic connectivity networks involved in aberrant behavioral control (i.e., executive control network), reward reactivity (i.e., basal ganglia network), and excessive self-focused and body-focused ruminations (i.e., default mode network) in the onset and maintenance of eating disturbances. However, examinations of large-scale resting-state networks that support the role of cognitive control, reward sensitivity, and self-directed thinking in disordered eating have rarely involved non-clinical samples from the general population. This study, involving a total of 693 healthy young adults (68.69% females; mean age, 18.37 years), investigated these issues by using pre-defined functional regions of interest from the executive control network, basal ganglia network, default mode network, and a seed-based region of interest-to-region of interest approach. After statistically controlling for differences in age, sex, body mass index, and head motion, we observed significant associations of higher levels of eating disorder symptoms, especially bulimia-type eating (i.e., binge eating and a combination of binge eating and compensatory behaviors, such as purging via self-induced vomiting or laxative use, and compulsive exercise), with weaker intra-network and inter-network functional synchrony. These results remained significant after excluding underweight, overweight, and obese participants. These findings suggest that these neural circuits may play a key role in the symptoms of disordered eating in healthy adults. They further reveal that the less efficient information exchange within and between intrinsic networks associated with self-referential thinking, inhibitory control, and reward sensitivity are strongly related to eating disorder symptoms. |
| Databáze: | OpenAIRE |
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