Biocompatibility and antibacterial properties of TiCu(Ag) thin films produced by physical vapor deposition magnetron sputtering
Autor: | Giovanna Iucci, Saqib Rashid, Edoardo Bemporad, Paolo Ascenzi, Daniela Visaggio, Paolo Visca, Giovanni Capellini, Gian Marco Vita, Martina Marsotto, Chiara Battocchio, Rostislav Daniel, Alessandra Di Masi, Marco Sebastiani, Luca Persichetti |
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Přispěvatelé: | Rashid, Saqib, Marco Vita, Gian, Persichetti, Luca, Iucci, Giovanna, Battocchio, Chiara, Daniel, Rostislav, Visaggio, Daniela, Marsotto, Martina, Visca, Paolo, Bemporad, Edoardo, Ascenzi, Paolo, Capellini, Giovanni, Sebastiani, Marco, di Masi, Alessandra |
Rok vydání: | 2022 |
Předmět: |
0303 health sciences
Settore FIS/03 Materials science Biocompatibility General Physics and Astronomy 02 engineering and technology Surfaces and Interfaces General Chemistry Nanoindentation Sputter deposition 021001 nanoscience & nanotechnology Condensed Matter Physics Microstructure Surfaces Coatings and Films Amorphous solid 03 medical and health sciences Chemical engineering Physical vapor deposition Crystallite Thin film 0210 nano-technology 030304 developmental biology biomaterials |
Zdroj: | Applied Surface Science |
ISSN: | 0169-4332 |
DOI: | 10.1016/j.apsusc.2021.151604 |
Popis: | Mechanical robustness, biocompatibility, and antibacterial performances are key features for materials suitable to be used in tissue engineering applications. In this work, we investigated the link existing between structural and functional properties of TiCu(Ag) thin films deposited by physical vapor deposition magnetron sputtering on Si substrates. The thin films were characterized by X-ray diffraction (XRD), nanoindentation, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS). The TiCu(Ag) thin films showed complete amorphous structure and improved mechanical properties in comparison with pure Ti films. However, for contents in excess of 20% Ag, we observed the appearance of nanometric Ag crystallite. The TiCu(Ag) thin films displayed excellent biocompatibility properties, allowing adhesion and proliferation of the human fibroblasts MRC-5 cell line. Moreover, all the investigated TiCu(Ag) alloy display bactericidal properties, preventing the growth of both Pseudomonas aeruginosa and Staphylococcus aureus. Results obtained from biological tests have been correlated to the surface structure and microstructure of films. The excellent biocompatibility and bactericidal properties of these multifunctional thin films opens to their use in tissue engineering applications. |
Databáze: | OpenAIRE |
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