Sex differences in the severity of neuropsychiatric symptoms and their relationship with clinico-demographic and psychosocial factors in patients with amnestic mild cognitive impairment and mild Alzheimer's disease
| Autor: | Kazutaka Nukariya, Masahiro Shigeta, Shunichiro Shinagawa, Keisuke Inamura, Yuri Tsuneizumi, Kenji Tagai, Tomoyuki Nagata |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Psychological intervention Disease Neuropsychological Tests Irritability 03 medical and health sciences 0302 clinical medicine Sex Factors Alzheimer Disease Internal medicine mental disorders medicine Humans In patient Cognitive Dysfunction Cognitive decline Cognitive impairment 030214 geriatrics business.industry Cognition respiratory system Psychiatry and Mental health Female Amnesia Geriatrics and Gerontology Pshychiatric Mental Health medicine.symptom business Gerontology Psychosocial 030217 neurology & neurosurgery |
| Zdroj: | Agingmental health. 24(3) |
| ISSN: | 1364-6915 |
| Popis: | Objectives: We examined differences in the severity of neuropsychiatric symptoms (NPS) according to sex and identified NPS-related clinico-demographic and psychosocial factors among community-living patients with amnestic-mild cognitive impairment (a-MCI) or mild Alzheimer's disease (AD).Method: Overall, 111 patients (44 males, 67 females) with mild a-MCI (n = 64) or mild AD (n = 47) were included. We divided the patients according to sex and compared their clinico-demographic and psychosocial factors, explored the severity of NPS using the subscales from the Neuropsychiatric Inventory-Questionnaire (NPI-Q), and further identified variables related to NPS.Results: Significant differences in several clinico-demographic and psychosocial characteristics were observed between the sexes. The severity of delusions was higher among females (mean, 0.48; SD, 1.60) than males (mean, 0.23; SD, 1.07; p = .02), while the severity of irritability was higher among males (mean, 0.97; SD, 1.92) than females (mean, 0.49; SD, 1.40; p = .03). The severity of delusions among females was related to the duration of cognitive decline (B = 0.37, p = .03), while the severity of irritability among males was related to general cognition (B = -0.40, p = .003).Conclusion: The severity of NPS among patients with a-MCI or mild AD differed according to sex. We identified NPS-related clinico-demographic factors among these patients. Sex differences should be considered when determining the need for NPS interventions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|