Phase II trial of 5-fluorouracil, adriamycin and cisplatin (FAP) in advanced gastric cancer
| Autor: | D. J. T. Wagener, H. Scheerder, G. J. Hoogendoorn, H. F. P. Hillen, T. Wobbes, S. H. Yap, J. T. M. Burghouts, F. E. Van Dam, S. G. L. Van Der Vegt |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Nausea medicine.medical_treatment Adenocarcinoma Toxicology Gastroenterology Bone Marrow Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Pharmacology (medical) Aged Pharmacology Cisplatin Chemotherapy business.industry Stomach Mitomycin C Middle Aged medicine.disease Surgery medicine.anatomical_structure Oncology Doxorubicin Fluorouracil Vomiting Drug Evaluation Female medicine.symptom business medicine.drug |
| Zdroj: | Cancer Chemotherapy and Pharmacology. 15:86-87 |
| ISSN: | 1432-0843 0344-5704 |
| DOI: | 10.1007/bf00257302 |
| Popis: | Twenty patients (15 male, 5 female) with nonresectable gastric adenocarcinoma were treated with FAP (5-fluorouracil 300 mg/m2 IV on days 1-5, adriamycin 50 mg/m2 IV on day 1, cisplatin 20 mg/m2 IV on days 1-5). Each course was repeated every 21 days. Eighteen patients were evaluable for response. The median age was 51 years, the range extending from 34 to 68. None had undergone chemotherapy. The median Karnofsky performance score was 80%. Nine (50%) partial responses (PR) and eight (44%) cases of stable disease (SD) were observed. One patient showed progression of the disease and died after 6 months. The median duration of response was 6+ months for PR and 6 months for SD. The median survival was 12 months. FAP toxicity was moderate, with the median WBC nadir 3.2 X 10(9)/l (range 0.7-4.2). One patient in PR died of septicemia. Nausea and vomiting were not dose-limiting. Neuropathy was mild in four and moderate in two patients. This FAP combination appears to be as effective with respect to response rate and duration as reported for 5-fluorouracil, adriamycin and mitomycin C (FAM). |
| Databáze: | OpenAIRE |
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