Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury
| Autor: | Mark A. Korsten, Preeti Anand, Bing Gong, Miroslav Radulovic |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Gastrointestinal
medicine.medical_specialty Dysmotility chemistry.chemical_element Review Myocytes smooth muscle Calcium symbols.namesake Internal medicine medicine Myocyte Ion channel Gastrointestinal dysmotility business.industry Gastroenterology Depolarization Smooth muscle contraction Interstitial cell of Cajal Endocrinology chemistry Interstitial cells of Cajal Ion channels symbols Neurology (clinical) business Acetylcholine medicine.drug |
| Zdroj: | Journal of Neurogastroenterology and Motility |
| ISSN: | 2093-0887 2093-0879 |
| DOI: | 10.5056/jnm15061 |
| Popis: | Gastrointestinal (GI) dysmotility is a severe, and common complication in patients with spinal cord injury (SCI). Current therapeutic methods using acetylcholine analogs or laxative agents have unwanted side effects, besides often fail to have desired effect. Various ion channels such as ATP-sensitive potassium (KATP) channel, calcium ions (Ca(2+))-activated potassium ions (K(+)) channels, voltage-sensitive Ca(2+) channels and chloride ion (Cl(-)) channels are abundantly expressed in GI tissues, and play an important role in regulating GI motility. The release of neurotransmitters from the enteric nerve terminal, innervating GI interstitial cells of Cajal (ICC), and smooth muscle cells (SMC), causes inactivation of K(+) and Cl(-) channels, increasing Ca(2+) influx into cytoplasm, resulting in membrane depolarization and smooth muscle contraction. Thus, agents directly regulating ion channels activity either in ICC or in SMC may affect GI peristalsis and would be potential therapeutic target for the treatment of GI dysmotility with SCI. |
| Databáze: | OpenAIRE |
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