Plumbagin Induces Cell Cycle Arrest and Apoptosis in A431 Cisplatin-Resistant Cancer Cells
| Autor: | Veronica Cocetta, Maria Carrara, Eugenio Ragazzi, Isabella Giacomini, Monica Montopoli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell cycle checkpoint
medicine.medical_treatment cisplatin Plant Science 01 natural sciences retinoblastoma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery Medicine cancer plumbagin Pharmacology Cisplatin Chemotherapy quinones drug resistance business.industry Cancer ROS General Medicine Plumbagin Cell cycle medicine.disease 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Apoptosis 030220 oncology & carcinogenesis Cancer cell Cancer research plumbagin quinones cisplatin cancer drug resistance ROS cell cycle retinoblastoma cell cycle business medicine.drug |
| Popis: | The onset of drug resistance represents the leading cause of chemotherapy failure in clinics. In the last decades, natural compounds have emerged as possible anticancer strategies used either alone or in combination with chemotherapeutic drugs, in order to overcome drug resistance. In fact, plant-derived therapies present biological activity and minimal side effects showing promising roles in the resensitization of resistant cancer cells. This work was aimed at investigating the anticancer potential of the natural naphthoquinone plumbagin in a cisplatin-resistant cancer cell line. The results indicated cytotoxic and pro-oxidant activity of plumbagin in both sensitive (A431wt) and cisplatin-resistant (A431/Pt) human cervix squamous carcinoma cell lines. Moreover, plumbagin treatment induced cell cycle arrest and apoptosis in A431/Pt cells and the inhibition of retinoblastoma complex, suggesting a stronger activity on the cisplatin-resistant cell line. Taken together, the data indicate appreciable in vitro anticancer activity of plumbagin, suggesting that this natural compound could become a tool to overcome cisplatin resistance. Although further studies are necessary, this work underlines a promising role of plumbagin in the resensitization of cisplatin-resistant cancer cells. |
| Databáze: | OpenAIRE |
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