Identification of a synonymous variant in TRIM59 gene for gastric cancer risk in a Chinese population
| Autor: | Chi Huang, Li Yang, Chao Yang, Xiangkun Huan, Hao Fan, Younan Wang, Zekuan Xu, Dakui Luo |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Genotype medicine.medical_treatment Single-nucleotide polymorphism Liver transplantation Polymerase Chain Reaction Polymorphism Single Nucleotide Tripartite Motif Proteins 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Stomach Neoplasms Polymorphism (computer science) Internal medicine Metalloproteins synonymous variant medicine Humans Genetic Predisposition to Disease TRIM59 International HapMap Project Allele Aged Genetics business.industry gastric cancer Intracellular Signaling Peptides and Proteins Membrane Proteins Cancer Heterozygote advantage Middle Aged medicine.disease 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Chinese population business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.14075 |
| Popis: | // Dakui Luo 1, * , Younan Wang 1, * , Xiangkun Huan 1, * , Chi Huang 1, * , Chao Yang 2 , Hao Fan 1 , Zekuan Xu 1 , Li Yang 1 1 Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China 2 Liver Transplantation Center of the First Affiliated Hospital and Key Laboratory on Living Donor Liver Transplantation, Ministry of Health, Nanjing Medical University, Nanjing, Jiangsu, China * These authors have contributed equally to this work Correspondence to: Li Yang, email: pwkyangli@163.com Keywords: gastric cancer, TRIM59, synonymous variant, genotype, Chinese population Received: July 13, 2016 Accepted: November 22, 2016 Published: December 21, 2016 ABSTRACT Tripartite motif 59 (TRIM59) is a novel oncogenic driver in gastric cancer (GC) that is implicated in disease progression as well as dismal survival. Genetic variants in peculiar gene are likely candidates for conferring hereditary susceptibility. The role of TRIM59 polymorphism in predicting the risk of malignant diseases and its relevance to TRIM59 expression have not been discussed. Using a HapMap tagSNPs approach, we screened three tag TRIM59 single nucleotide polymorphisms (SNPs) (rs1141023G>A, rs7629A>G, rs11706810T>C) which were genotyped in 602 GC patients and 868 healthy controls. Our study provided convincing result that carries of variant rs1141023A allele markedly increased GC risk (P=0.006). In comparison with the GG homozygotes, the variant GA heterozygotes demonstrated 1.50-fold elevated risk of GC (p=0.014, 95% confidence interval [CI] = 1.09–2.08). Subjects who carried the (GA+AA) genotypes of rs1141023 were associated with remarkable increased GC risk compared with the common genotype (P = 0.013, adjusted OR = 1.50, 95% CI = 1.09–2.05). Further stratified analyses displayed that the relationship between mutant genotype of rs1141023 and GC risk was more profound in male individuals. Intriguingly, there is no significant distinction of TRIM59 mRNA expression between rs1141023GA genotype and GG genotype in 44 normal gastric tissues. Taken together, our results suggest that rs1141023 polymorphism contributes to increased predisposition to GC and thus may be responsible for predicting early GC. |
| Databáze: | OpenAIRE |
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