Colored collagen is a long-lasting point marker for small pulmonary nodules in thoracoscopic operations
| Autor: | Hiroaki Nomori, Hirotoshi Horio |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male Pathology medicine.medical_specialty Lung Neoplasms Iohexol Drug Evaluation Preclinical chemistry.chemical_compound Colored collagen medicine Thoracoscopy Animals Humans Lung Aged Aged 80 and over Lagomorpha biology medicine.diagnostic_test business.industry Solitary Pulmonary Nodule Nodule (medicine) Middle Aged medicine.disease biology.organism_classification Methylene Blue Contrast medium Drug Combinations medicine.anatomical_structure chemistry Pneumothorax Drug Evaluation Surgery Female Collagen Rabbits medicine.symptom Cardiology and Cardiovascular Medicine Nuclear medicine business Tomography X-Ray Computed Methylene blue |
| Zdroj: | The Annals of thoracic surgery. 61(4) |
| ISSN: | 0003-4975 |
| Popis: | Background. To locate small deep pulmonary nodules under thoracoscopy, we developed a long-lasting point marker termed "colored collagen." Methods. Colored collagen is composed of 0.8% atelocollagen, 5% methylene blue, and 32% contrast medium. The affinity between atelocollagen and methylene blue was examined in a washing test using 2 mol/L of NaCl. For clinical application, a computed tomography-guided colored collagen injection was performed in 11 patients to localize 11 deep pulmonary nodules, which were less than 20 mm in diameter. Results. The washing test showed that atelocollagen and methylene blue combined with each other firmly. An experimental study using rabbit lung showed that the colored collagen stayed at the injection site for 10 days without toxicity. In clinical application, the colored collagen could be seen as a clear spot using thoracoscopy 1 to 4 days after the injection in all of the 11 pulmonary nodules. There was no complication except for a slight pneumothorax in 2 patients. Conclusions. The colored collagen, because it stays in the injected site for a long time, solves the problem of the single dye injection method, which requires both a computed tomographic scan and an operating room simultaneously, and also the colored collagen, because of its point dyeing, can mark the nodule more accurately than a single dye. |
| Databáze: | OpenAIRE |
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