Neurocognitive disorder in hypertensive patients. Heart–Brain Study
| Autor: | R. Flores, R.M. Ruffa, P. Forcada, R. Plunkett, A.E. De Cerchio, Augusto Vicario, M.E. Giuliano, Gustavo H. Cerezo, N. Lodolo, S. Hauad, J Zilberman, M. Del Sueldo, S M Pawluk |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Urban Population Population Argentina Blood Pressure 030204 cardiovascular system & hematology Hospital Anxiety and Depression Scale Executive Function 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal Medicine Humans Medicine Cognitive Dysfunction education Aged Memory Disorders education.field_of_study Anthropometry business.industry Age Factors Cognition Middle Aged Mental Status and Dementia Tests Executive functions Cognitive test Cross-Sectional Studies Blood pressure Hypertension Female Cardiology and Cardiovascular Medicine business Neurocognitive 030217 neurology & neurosurgery Executive dysfunction |
| Zdroj: | Hipertensión y Riesgo Vascular. 35:169-176 |
| ISSN: | 1889-1837 |
| DOI: | 10.1016/j.hipert.2018.01.004 |
| Popis: | The relation between hypertension and cognitive impairment is an undisputable fact. The aims of this study were to determine the prevalence of cognitive impairment in hypertensive patients, to identify the most affected cognitive domain, and to observe the association with different parameters of hypertension and other vascular risk factors. A multicentre study was carried out, and 1281 hypertensive patients of both genders and ≥21 years of age were included. Data on the following parameters were obtained: cognitive status (Minimal Cognitive Examination), behavioural status (Hospital Anxiety and Depression Scale), blood pressure, anthropometry, and biochemical profile. The average age was 60.2±13.5 years (71% female), and the educational level was 9.9±5.1 years. Global cognitive impairment was seen in 22.1%, executive dysfunction in 36.2%, and semantic memory impairment in 48.9%. Cognitive impairment was higher in males (36.8% vs. 30.06%) within both the 70-79-year-old and the ≥80-year-old (50% vs. 40%) age groups. Abnormal Clock Drawing Test results were related to high pulse pressure (p0.0036), and abnormal Mini-Boston Naming Test results to both high systolic blood pressure (p0.052) and pulse pressure (p0.001). The treated/uncontrolled hypertensive group showed abnormal results both in the Mini Mental State Examination (OR, 0.73; p=0.036) and the Mini-Boston Naming Test (OR, 1.36; p=0.021). Among patients without cognitive impairment (MMSE24), 29.4% presented executive dysfunction, and 41.5% semantic memory impairment. Cognitive impairment was higher in hypertensive patients than in the general population. Executive functions and semantic memory were the most affected cognitive domains. High systolic blood pressure and pulse pressure were associated with abnormal results in cognitive tests. |
| Databáze: | OpenAIRE |
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