Genetic prion disease: opportunities for early therapeutic intervention with rigorous pre-symptomatic trials

Autor:	Inga Zerr, Jan C. Koch, Peter Hermann
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine animal diseases PRNP protein human Scrapie Disease Bioinformatics Prion Proteins Prion Diseases 03 medical and health sciences 0302 clinical medicine Intervention (counseling) genetics [Prion Diseases] Medicine Animals Humans Pharmacology (medical) ddc:610 Prion protein Pharmacology drug therapy [Prion Diseases] business.industry General Medicine nervous system diseases 3. Good health 030104 developmental biology nervous system Research Design 030220 oncology & carcinogenesis Mutation genetics [Prion Proteins] business
Zdroj:	Expert opinion on investigational drugs 29(12), 1313-1316 (2020). doi:10.1080/13543784.2020.1839048
DOI:	10.1080/13543784.2020.1839048
Popis:	Human prion diseases are associated with misfolded prion protein (Prion Protein Scrapie, PrPSc) causing rapidly and irreversibly progressive encephalopathic syndromes. PrPSc builds insoluble aggreg...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becc24921d4f1d76ce020edf3c8a0bec https://pub.dzne.de/record/154236 Zobrazit plný text záznamu