Heart rate reduction with esmolol in septic shock: effects on microcirculation
| Autor: | C Raffone, Annalia D'Egidio, Paolo Pietropaoli, Abele Donati, C Scarcella, A Di Russo, Martin Westphal, Roberta Domizi, F D'Ippolito, S. Rehberg, Andrea Carsetti, Christian Ertmer, Andrea Morelli |
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| Rok vydání: | 2012 |
| Předmět: |
Inotrope
Chronotropic Cardiac output medicine.medical_specialty business.industry Septic shock Hemodynamics Critical Care and Intensive Care Medicine medicine.disease Esmolol Microcirculation Internal medicine Poster Presentation Heart rate Cardiology Medicine business Intensive care medicine medicine.drug |
| Zdroj: | Critical Care |
| Popis: | Preclinical and clinical studies report that β-blockers may be an interesting option to attenuate the deleterious effects of prolonged catecholamine exposure during septic shock. Nevertheless, there are concerns that β-blockers may have negative chronotropic and inotropic effects leading to inappropriately low cardiac output. The objective of the present study was therefore to elucidate whether a reduction in heart rate (HR) with esmolol may negatively affect microcirculation in patients with septic shock who remained tachycardic after hemodynamic optimization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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