Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction

Autor:	Storm Hassell-Hart, Elisa Speranzini, Sirihathai Srikwanjai, Euan Hossack, S. Mark Roe, Daren Fearon, Daniel Akinbosede, Stephen Hare, John Spencer
Rok vydání:	2022
Předmět:	Thiazoles Bacteria Organic Chemistry Physical and Theoretical Chemistry Iridium Biochemistry Catalysis Sulfur
Zdroj:	Organic letters. 24(43)
ISSN:	1523-7052
Popis:	A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becb1b86d2ff9f8a25eb2a7266e883c2 https://pubmed.ncbi.nlm.nih.gov/36265082 Zobrazit plný text záznamu