| Autor: |
Caitlin A, Harrington, Rebecca A, Carr, Meier, Hsu, Kay See, Tan, Smita, Sihag, Prasad S, Adusumilli, Manjit S, Bains, Matthew J, Bott, James M, Isbell, Bernard J, Park, Gaetano, Rocco, Valerie W, Rusch, David R, Jones, Daniela, Molena |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
The Journal of Thoracic and Cardiovascular Surgery. 164:411-419 |
| ISSN: |
0022-5223 |
| Popis: |
Little is known about the pattern of nodal metastases in patients with esophageal adenocarcinoma who have received neoadjuvant chemoradiation and undergone surgery. We sought to assess this pattern and evaluate its association with prognosis.All patients with esophageal adenocarcinoma who underwent neoadjuvant chemoradiation and R0 esophagectomy between 2010 and 2018 at our institution were included (n = 537). The primary objective was to evaluate the association of sites of lymph node metastases with disease-free survival. The number of nodal stations and individual sites of nodal metastases were evaluated first in univariable then in separate multivariable Cox regression models adjusted for clinical factors.Of 537 patients, 193 (36%) had pathologic nodal metastases at the time of surgery; 153 (28%) had single-station disease, 32 (6.0%) had 2-station disease, and 8 (1.5%) had 3-station disease. The majority of patients with multiple positive nodal stations had positive nodes in the paraesophageal (93%) and/or left gastric stations (60%). Multivariable models controlling for clinical factors showed that an increasing number of positive nodal stations (hazard ratio, 1.59; 95% CI, 1.35-1.84; P .01)-in particular, the subcarinal (hazard ratio, 2.78; 95% CI, 1.54-5.03; P .01) and paraesophageal stations (hazard ratio, 2.0; 95% CI, 1.58-2.54; P .01)-was associated with increased risk of recurrence.One-third of patients who have undergone R0 resection for esophageal adenocarcinoma following induction chemoradiation therapy have metastatic lymph nodes. An increasing number of nodal stations, particularly paraesophageal and subcarinal metastases, were associated with increased risk of recurrence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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