Impact of aldosterone on left ventricular structure and function in young normotensive and mildly hypertensive subjects
| Autor: | Roland E. Schmieder, Karl F. Hilgers, Markus P. Schlaich, Hans P. Schobel |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Diastole Blood Pressure Sodium Chloride Essential hypertension Ventricular Function Left Muscle hypertrophy Excretion chemistry.chemical_compound Internal medicine medicine Humans Salt intake Aldosterone business.industry Blood Pressure Monitoring Ambulatory medicine.disease Blood pressure Endocrinology chemistry Hypertension Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American Journal of Cardiology. 85:1199-1206 |
| ISSN: | 0002-9149 |
| Popis: | Left ventricular (LV) hypertrophy is an independent risk factor for cardiovascular morbidity and mortality. Experimental data revealed that elevated circulating aldosterone is associated with increased collagen accumulation resulting in myocardial fibrosis. To analyze whether aldosterone is also associated with cardiac structural and functional changes in humans, we examined the effects of aldosterone on LV structure and function before and after suppression of aldosterone by increasing oral salt intake. The study group comprised 26 normotensive male white healthy control subjects (age 26 ± 3 years) and 31 male white subjects (age 25 ± 3 years) with mild essential hypertension (World Health Organization stages I to II). Two-dimensional–guided M-mode echocardiography and 24-hour ambulatory blood pressure (BP) monitoring was performed in each subject. Simultaneously, we measured 24-hour urinary sodium excretion, 24-hour urinary aldosterone, and serum aldosterone concentration at baseline and after increasing oral salt intake to suppress aldosterone secretion. In all subjects LV mass correlated with body mass index (r = 0.42, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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