Kidney-Protective Effects of SGLT2 Inhibitors

Autor:	Biff F, Palmer, Deborah J, Clegg
Rok vydání:	2022
Předmět:	Transplantation Nephrology Epidemiology Critical Care and Intensive Care Medicine
Zdroj:	Clinical Journal of the American Society of Nephrology. 18:279-289
ISSN:	1555-905X 1555-9041
DOI:	10.2215/cjn.09380822
Popis:	The sodium-glucose cotransporter 2 (SGLT2) inhibitors have become an integral part of clinical practice guidelines to slow the progression of CKD in patients with and without diabetes mellitus. Although initially developed as antihyperglycemic drugs, their effect on the kidney is multifactorial resulting from profuse glycosuria and natriuresis consequent to their primary site of action. Hemodynamic and metabolic changes ensue that mediate kidney-protective effects, including (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec5a4bfddb104a29e435f6acfe2109f https://doi.org/10.2215/cjn.09380822 Zobrazit plný text záznamu