Sirtuin modulators: an updated patent review (2012 - 2014)
Autor: | Sergio Valente, Antonello Mai, Paolo Mellini |
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Rok vydání: | 2014 |
Předmět: |
Drug Industry
Human immunodeficiency virus (HIV) Anti-Inflammatory Agents Enzyme Activators Inflammation Antineoplastic Agents Disease Biology Bioinformatics medicine.disease_cause Neuroprotection Patents as Topic Structure-Activity Relationship Drug Discovery medicine Animals Humans Sirtuins Epigenetics Pharmacology Cellular metabolism Molecular Structure Cancer General Medicine medicine.disease Enzyme Activation Histone Deacetylase Inhibitors Neuroprotective Agents Drug Design Immunology Sirtuin biology.protein Anti-Obesity Agents medicine.symptom Signal Transduction |
Zdroj: | Expert opinion on therapeutic patents. 25(1) |
ISSN: | 1744-7674 |
Popis: | Since 2000 sirtuins (SIRT1-7) have gained growing attention for their connections with many biological processes such as cellular metabolism regulation, neuroprotection, apoptosis, inflammation, and cancer progression. In particular, SIRT1 has been the most studied isoform, not only for its role during caloric restriction but also as target in prevention of aging-related diseases. SIRT inhibition can be useful for treating cancer, HIV infection or muscular diseases, SIRT activation can exert positive effects in aging-related disorders such as metabolism, cardiovascular, and neurodegenerative diseases.This review includes the patents about sirtuin modulation released during the 2012 - 2014 period, and covers the potential therapeutic uses of known sirtuin modulators as well as new related small molecules in various disease contexts.The effective role of sirtuins in cancer is still controversial, because some of them seem to have tumor-promoter as well as tumor-suppressor properties. Thus, few patents describing SIRT inhibitors have been found in 2012 - 2014 period. Despite the still active debate on their role as direct or indirect activators of SIRT1, sirtuin-activating compounds are actually subjected to intense research for the ability to treat neurodegenerative diseases, metabolic disorders, inflammation, vascular system injuries, wound healing and endothelial dysfunctions. A great number of clinical trials are reported with either SIRT inhibitors or activators, thus it is possible that in the foreseeable future one or more of them will enter in the clinical arena. |
Databáze: | OpenAIRE |
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