Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells
| Autor: | Stefan H. Bossmann, Carl B. Myers, Xiaoxuan Leaym, Raja Shekar Rachakatla, Masaaki Tamura, Thilani N. Samarakoon, Hongwang Wang, Viktor Chikan, Sivasai Balivada, Franklin Orban Kroh, Gwi-Moon Seo, Olga Koper, Marla Pyle, Deryl L. Troyer, Brandon Walker, Raj Kumar Dani |
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| Rok vydání: | 2010 |
| Předmět: |
Proteomics
Materials science Iron Magnetic Field Therapy General Physics and Astronomy Nanotechnology Ferric Compounds Nervous System Article Mice Cell Line Tumor medicine Animals Humans General Materials Science Viability assay Cytotoxicity Melanoma Stem Cells Electric Conductivity Temperature General Engineering Biological Transport medicine.disease Neural stem cell Magnetic hyperthermia Biophysics Nanoparticles Magnetic nanoparticles Female Stem cell Stem Cell Transplantation |
| Zdroj: | ACS Nano. 4:7093-7104 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/nn100870z |
| Popis: | Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane-porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe3O4 MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p |
| Databáze: | OpenAIRE |
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