Targeting of TLE3 by miR‑3677 in human breast cancer promotes cell proliferation, migration and invasion
| Autor: | Xing‑Yan Deng, Jin‑Hui Zhang, Guang‑Hui Ren, Jian‑Hua Feng, Wen‑Song Cai, Xiao‑Xiong Gan, Li‑Na Peng, Bo Xu, Fei Shen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Cell Biology medicine.disease_cause Metastasis 03 medical and health sciences breast cancer 0302 clinical medicine microRNA medicine Gene silencing microRNA-3677 Oncogene Cell growth cell metastasis Articles Cell cycle transducin-like enhancer of Split3 medicine.disease cell proliferation 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research Carcinogenesis |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2019.11241 |
| Popis: | Numerous studies have indicated an important function of microRNAs (miRs) in breast cancer (BC) progression, oncogenesis and metastasis. However, the function of miR-3677, which has been revealed to be upregulated in BC [The Cancer Genome Atlas (TCGA) data], has not been investigated to date. In the present study, miR-3677 was revealed to be upregulated in BC as determined using TCGA. miR-3677 was significantly upregulated in BC tissues and cell lines compared with those noted in adjacent non-cancerous tissues and primary normal breast cells (P |
| Databáze: | OpenAIRE |
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