In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi
| Autor: | Arvind Kumar, D. G. J. Batista, J. S. De Araújo, D. W. Boykin, Moloy Banerjee, M. B. Meuser, Abdelbasset A. Farahat, C. F. Da Silva, Claudia Alessandra Fortes Aiub, M. F. V. da Silva, P. B. Da Silva, Maria de Nazaré Correia Soeiro, Chad E. Stephens, Carlos Fernando Araujo-Lima |
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| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
Male Chagas disease Trypanosoma cruzi Amidines Parasitic Sensitivity Tests Parasitemia Mice In vivo parasitic diseases medicine Animals Experimental Therapeutics Chagas Disease Pharmacology (medical) Trypanocidal agent Pharmacology biology Biological activity biology.organism_classification medicine.disease Trypanocidal Agents Virology In vitro Infectious Diseases Immunology |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 58:4191-4195 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.01403-13 |
| Popis: | Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo . All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo . Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi . |
| Databáze: | OpenAIRE |
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