Non-alcoholic fatty liver disease in obese persons with diabetes
| Autor: | Aleksandar Pavlovic, Ratko Tomasevic, Predrag Dugalic, Gradimir Golubovic, Zoran Gluvic, Dragana Stankovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology obesity Cirrhosis Gastroenterology fattyliver Diabetes mellitus Internal medicine Nonalcoholic fatty liver disease medicine Humans Pharmacology (medical) dyslipidemias lcsh:R5-920 medicine.diagnostic_test business.industry Fatty liver Type 2 Diabetes Mellitus medicine.disease Obesity Obesity Morbid Fatty Liver diagnosis therapy diabetes mellitus type 2 Liver biopsy treatment outcome Steatohepatitis business lcsh:Medicine (General) |
| Zdroj: | Vojnosanitetski Pregled, Vol 64, Iss 8, Pp 569-572 (2007) |
| ISSN: | 0042-8450 |
| Popis: | Background. Obesity, diabetes and different lipid metabolic disorders are the most frequent risk factors for nonalcoholic fatty liver disease, presented with a high variability in clinical and histological findings. Case report. We presented a case of 37-year-old male, suffering from type 2 diabetes mellitus, grade III obesity (BMI 45 kg/m2) and multiple metabolic disorders. Abdominal ultrasound revealed hepatomegaly during the last six months. Laboratory diagnostics showed increased serum transaminase levels. Serologic markers for viral hepatitis B and C were negative. The patient denied significant alcohol consumption. Liver biopsy and pathohistologic finding revealed macro- (III grade) and microvesicular (I grade) fatty degeneration, as well as mixed-cell portal infiltration with moderate liver fibrosis, corresponding to the typical presentation of NASH (Non Alcoholic Steatohepatitis). Conclusion. NASH treatment options include the reduction of body mass and an adequate antidiabetic and dislipidemia treatment. The aim of all therapeutic measures was to stop the progression of the disease, to prevent the progression of fibrosis and the development of of cirrhosis. . |
| Databáze: | OpenAIRE |
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