An unexpected role for PD-L1 in front-rear polarization and directional migration

Autor:	Miguel Sánchez-Álvarez, Miguel A. del Pozo
Rok vydání:	2022
Předmět:	Cell Movement Neoplasms T-Lymphocytes Programmed Cell Death 1 Receptor Humans Tumor Escape Cell Biology B7-H1 Antigen
Zdroj:	The Journal of cell biology. 221(5)
ISSN:	1540-8140
Popis:	Programmed cell death-ligand 1 (PD-L1)–mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front–rear polarity and directionally persistent cell migration, independently of PD-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebcedda8949631d802b375f853c3f9c https://pubmed.ncbi.nlm.nih.gov/35344032 Zobrazit plný text záznamu