Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019

Autor:	Mireia Jané, Javier Díez-Domingo, Roser Vendrell, Andrés Alonso-Cordero, M Del Mar Mosquera, Mariana Reyes-Prieto, Patricia Molina, Ana Isabel Martínez, Nuria Torner, Beatriz Mengual-Chuliá, Laura Cano, F. Xavier López-Labrador, M Angeles Marcos, Jordi Vila
Rok vydání:	2021
Předmět:	Favipiravir medicine.disease_cause Antiviral Agents Genome DNA sequencing 03 medical and health sciences Drug Resistance Viral Influenza Human Influenza A virus medicine Humans Pharmacology (medical) Polymerase 030304 developmental biology Pharmacology Whole genome sequencing 0303 health sciences biology Resistance (ecology) 030306 microbiology Virology Natural resistance Infectious Diseases Spain biology.protein
Zdroj:	Antimicrob Agents Chemother
ISSN:	1098-6596 0066-4804
Popis:	Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebca1370c662381f3d8684f833564ea https://doi.org/10.1128/aac.02718-20 Zobrazit plný text záznamu