Undifferentiated Pancreatic Cancer Associated with Humoral Hypercalcemia of Malignancy
| Autor: | Teruo Yoshinaga, Masatomo Mori, Hisashi Takayama, Naoko Ohya, Hitoshi Takagi, Takeaki Nagamine, Satoru Kakizaki, Riko Kitazawa, Tsugio Higuchi |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Pamidronate chemistry.chemical_element Antineoplastic Agents Technetium Malignancy Pancreatic tumor Pancreatic cancer Biopsy medicine Humans Radiology Nuclear Medicine and imaging Diphosphonates Parathyroid hormone-related protein medicine.diagnostic_test business.industry Carcinoma Liver Neoplasms Parathyroid Hormone-Related Protein Proteins General Medicine Middle Aged Bisphosphonate medicine.disease Pancreatic Neoplasms Oncology chemistry Hypercalcemia Immunohistochemistry business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Japanese Journal of Clinical Oncology. 28:563-566 |
| ISSN: | 1465-3621 0368-2811 |
| Popis: | We present a case of undifferentiated pancreatic cancer associated with humoral hypercalcemia of malignancy (HHM) in which parathyroid hormone-related protein (PTH-rP) is identified as the causative factor of hypercalcemia. A 61-year-old man was hospitalized with right hypochondralgia. Ultrasound examination and computed tomography demonstrated a large mass in the pancreatic head with liver metastases. Biopsy of the pancreatic tumor demonstrated undifferentiated carcinoma. Serum calcium level and PTH-rP were elevated. Bone scan with technetium-99 demonstrated no accumulation in the bones. Immunohistochemical staining for PTH-rP was weakly positive in the tumor cells. We considered that PTH-rP was the causative factor of HHM in this case from laboratory data and immunohistochemical findings. This rare case was successfully treated with pamidronate disodium, which is a type of bisphosphonate derivative. We compared this case with previously reported cases. |
| Databáze: | OpenAIRE |
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