Clinical Outcomes for Diabetic Foot Ulcers Treated with Clostridial Collagenase Ointment or with a Product Containing Silver
| Autor: | David Innes Cargill, Joseph M. Caporusso, Jaime E. Dickerson, Travis Motley, Robert A. Eichelkraut, Darrell L. Lange |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment wound healing 030209 endocrinology & metabolism macromolecular substances Critical Care and Intensive Care Medicine Gastroenterology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Primary outcome Secondary outcome Internal medicine medicine silver Discovery Express Debridement business.industry Incidence (epidemiology) medicine.disease Diabetic foot infection collagenase Diabetic foot ulcer Emergency Medicine Collagenase business diabetic foot ulcer debridement medicine.drug |
| Zdroj: | Advances in Wound Care |
| ISSN: | 2162-1934 2162-1918 |
| DOI: | 10.1089/wound.2018.0784 |
| Popis: | Objective: To compare outcomes of diabetic foot ulcers (DFUs) treated with clostridial collagenase ointment (CCO) or silver-containing products, both in combination with sharp debridement as needed. Approach: One hundred two subjects with qualifying DFUs were randomized to daily treatment with either CCO or a silver-containing product for 6 weeks followed by a 4 -week follow-up period. The primary outcome was the mean percent reduction in DFU area. A secondary outcome was the incidence of ulcer infections between groups. Results: At the end of treatment, the mean percent reduction in area from baseline of DFUs treated with CCO was 62% (p |
| Databáze: | OpenAIRE |
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