Synthesis of Pyridyl-dihydrobenzooxaphosphole Ligands and Their Application in Asymmetric Hydrogenation of Unfunctionalized Alkenes

Autor:	Nathan K. Yee, Sonia Rodriguez, Carl A. Busacca, Shengli Ma, Jolaine Savoie, Bo Qu, Lalith P. Samankumara, Chris H. Senanayake, Nizar Haddad, Daniel R. Fandrick, Heewon Lee, Jinhua J. Song, Xudong Wei
Rok vydání:	2014
Předmět:	Sulfonyl chemistry.chemical_classification Molecular Structure Pyridines Chemistry Organic Chemistry Asymmetric hydrogenation Stereoisomerism Alkenes Phosphorus Compounds Iridium Ligands Combinatorial chemistry Catalysis Nucleophilic aromatic substitution Organic chemistry Hydrogenation
Zdroj:	The Journal of Organic Chemistry. 79:993-1000
ISSN:	1520-6904 0022-3263
Popis:	Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the corresponding sulfonyl pyridines. The ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes with good enantioselectivities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb83ee31756a6a052c9e703012a84ad https://doi.org/10.1021/jo4024864 Zobrazit plný text záznamu