Anti-inflammatory isocoumarins from the bark of Fraxinus chinensis subsp. rhynchophylla

Autor:	KwangWon Hong, Beom Zoo Lee, Sulhae Lee, Ik-Soo Lee, Soon-Kyu Jeong, Chan-Sik Kim
Rok vydání:	2020
Předmět:	Traditional medicine Chemistry medicine.drug_class Organic Chemistry Isocoumarins Anti inflammation Plant Science Biochemistry Anti-inflammatory Analytical Chemistry Isocoumarin chemistry.chemical_compound visual_art medicine visual_art.visual_art_medium Bark Fraxinus chinensis
Zdroj:	Natural Product Research. 35:4380-4387
ISSN:	1478-6427 1478-6419
DOI:	10.1080/14786419.2020.1715401
Popis:	A new isocoumarin (1) named fraxicoumarin was isolated from the bark of Fraxinus chinensis subsp. rhynchophylla along with three known compounds (2–4). The structure of the new compound was established by extensive spectroscopic studies and chemical evidence. The anti-inflammatory effects of the isolated compounds (1–4) on lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells were evaluated in vitro. Of the compounds tested, compounds 1 and 3 inhibited LPS-induced nitric oxide (NO) production in RAW 264.7 cells. Consistent with these findings, they also suppressed LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein level in RAW 264.7 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb7dfef359d7a19aadef2a2c1ac31cf https://doi.org/10.1080/14786419.2020.1715401 Zobrazit plný text záznamu