Remote magnetic switch off microgate for nanofluidic drug delivery implants
| Autor: | Alessandro Grattoni, Usha Thekkedath, Danilo Demarchi, Gianluca Torchio, Giulia Rizzo, Marco Farina, Andrea Ballerini |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_specialty media_common.quotation_subject Finite Element Analysis Biomedical Engineering 02 engineering and technology 03 medical and health sciences Drug Delivery Systems Medicine Nanotechnology Dosage adjustment Adverse effect Intensive care medicine Molecular Biology Time sensitive media_common business.industry Rhodamines Drug administration Prostheses and Implants Magnetic switch 021001 nanoscience & nanotechnology 030104 developmental biology Magnetic Fields Proof of concept Drug delivery 0210 nano-technology business Biomedical engineering |
| Popis: | In numerous pathologies, implantable drug delivery devices provide advantages over conventional oral or parenteral approaches. Based on the site of implantation and release characteristics, implants can afford either systemic delivery or local administration, whereby the drug is delivered at or near the site of intended action. Unfortunately, current implantable drug delivery systems provide limited options for intervention in the case of an adverse reaction to the drug or the need for dosage adjustment. In the event that drug delivery must be terminated, an urgent surgical retrieval may be the only reliable option. This could be a time sensitive and costly effort, requiring access to trained professionals and emergency medical facilities. To address such limitations, here we demonstrate, in vitro and ex vivo, a novel microsystem for the rapid and effective switch off of drug delivery from an implantable nanofluidic system, by applying a safe external electromagnetic field in the FDA approved dose range. This study represents a proof of concept for a technology with potential for broad applicability to reservoir-based delivery implants for both complete interruption or remote titration of drug administration. |
| Databáze: | OpenAIRE |
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