Therapy for Alopecia Areata in Mice by Stimulating the Hair Cycle with Parathyroid Hormone Agonists Linked to a Collagen-Binding Domain
| Autor: | Ranjitha Katikaneni, Andrew W. Seymour, Robert C. Gensure, Rohan Gulati, Tulasi Ponnapakkam |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Beta-catenin Alopecia Areata Recombinant Fusion Proteins Parathyroid hormone Dermatology Mice Animal model Hair cycle Internal medicine Medicine Animals skin and connective tissue diseases Molecular Biology beta Catenin integumentary system biology business.industry Cell Biology General Medicine Alopecia areata medicine.disease Hair follicle 3. Good health Disease Models Animal medicine.anatomical_structure Endocrinology Hair loss Parathyroid Hormone biology.protein sense organs business Hair Follicle hormones hormone substitutes and hormone antagonists Biotechnology Binding domain Hair |
| Zdroj: | The journal of investigative dermatology. Symposium proceedings. 17(2) |
| ISSN: | 1529-1774 |
| Popis: | Alopecia areata is a common disorder in which autoimmune destruction of hair follicles results in patchy hair loss. Currently there is no adequate therapy, although immune modulator therapies are currently in development. Parathyroid hormone (PTH) is a hair cycle stimulator which shows promise in treating various forms of alopecia, although its short half-life limits its clinical use. PTH-CBD is a PTH analog which binds collagen, prolonging retention in skin. We tested effects of PTH-CBD in C3H/HeJ-engrafted mice, the animal model for alopecia areata, on hair growth and found that a significant proportion of animals had reduced hair loss (PTH-CBD: 13/21, 62% vs. control: 3/10, 30%; P |
| Databáze: | OpenAIRE |
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