Maternal vitamin D levels during pregnancy and neonatal health: evidence to date and clinical implications
| Autor: | Johannes M. van den Ouweland, Giovanna Muscogiuri, Spyridon N. Karras, Anna Maria Colao, Kalliopi Kotsa, Hana Fakhoury, William B. Grant |
|---|---|
| Přispěvatelé: | Karras, Spyridon N, Fakhoury, Hana, Muscogiuri, Giovanna, Grant, William B, van den Ouweland, Johannes M, Colao, Annamaria, Kotsa, Kalliopi |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Offspring infectious disease Reviews 030209 endocrinology & metabolism law.invention Sepsis small for gestational age 03 medical and health sciences 0302 clinical medicine Rheumatology Randomized controlled trial law Medicine Orthopedics and Sports Medicine 030212 general & internal medicine Pregnancy business.industry Obstetrics preterm birth medicine.disease Low birth weight Regimen hypovitaminosis D Small for gestational age Observational study pregnancy medicine.symptom business |
| Zdroj: | Therapeutic Advances in Musculoskeletal Disease. 8:124-135 |
| ISSN: | 1759-7218 1759-720X |
| DOI: | 10.1177/1759720x16656810 |
| Popis: | Low maternal vitamin D levels during pregnancy have been associated with a plethora of adverse neonatal outcomes, including small for gestational age and preterm births, detrimental effect on offspring bone and teeth development, and risk of infectious diseases. Although most observational studies indicate a significant linear relationship between maternal 25-hydroxyvitamin D and the above outcomes, some randomized controlled trials to date are inconclusive, mostly due to differences in study design and supplementation regimen. The currently available results indicate that vitamin D supplementation during pregnancy reduces the risk of preterm birth, low birth weight, dental caries of infancy, and neonatal infectious diseases such as respiratory infections and sepsis. This narrative review aims to summarize available trial results regarding the effect of low maternal vitamin D levels during pregnancy, in conjunction with neonatal outcomes on the field, with a discourse on the appropriate clinical approach of this important issue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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