Ocat, a Paternally Expressed Gene Closely Linked and Transcribed in the Opposite Direction to Peg3
| Autor: | M. Azim Surani, Li-Lan Li, Irene Y.Y. Szeto |
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| Rok vydání: | 2000 |
| Předmět: |
Male
DNA Complementary Transcription Genetic Genetic Linkage Molecular Sequence Data Kruppel-Like Transcription Factors Biology Bone and Bones Genomic Imprinting Mice Exon Gene mapping Pregnancy Transcription (biology) Complementary DNA Genetics Animals Allele Gene Chromosome 7 (human) Gene Expression Profiling Gene Expression Regulation Developmental Proteins Embryo Mammalian Molecular biology Mice Inbred C57BL Muridae Gene Expression Regulation Female Genomic imprinting Protein Kinases Transcription Factors |
| Zdroj: | Genomics. 67:221-227 |
| ISSN: | 0888-7543 |
| Popis: | Two reciprocally imprinted Kruppel-type zinc finger genes, Peg3 and Zim1, have been found in close proximity on mouse proximal chromosome 7. Here, we describe the identification of another novel imprinted transcript, Ocat (ossification center-associated transcript). Ocat encodes a 5.5-kb spliced transcript and is transcribed in the opposite orientation to Peg3. One of its exons (putative exon 1) lies approximately 200 bp upstream of Peg3. Ocat is predominantly expressed in embryos from days 11 to 17, particularly in ossification centers of the embryonic skeleton at day 15. Like Peg3, Ocat is expressed exclusively from the paternal allele. Despite their proximity, Peg3 and Ocat showed dissimilar expression profiles, suggesting that they are regulated by independent genetic elements. |
| Databáze: | OpenAIRE |
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