The Influence of Indigenous Segmented Filamentous Bacteria on Small Intestinal Transit in Mice
| Autor: | P. J. Heidt, M. E. Van Den Brink, F. G. J. Poelma, M. H. Bakker, J. Snel |
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| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Clostridium innocuum Ratón Segmented filamentous bacteria General Engineering Ileum Biology biology.organism_classification digestive system Microbiology Small intestine medicine.anatomical_structure medicine General Earth and Planetary Sciences Morganella morganii Pathogen Bacteria General Environmental Science |
| Zdroj: | Microbial Ecology in Health and Disease; Vol 9, No 5 (1996) |
| ISSN: | 0891-060X 1651-2235 |
| Popis: | The indigenous microbiota of healthy animals is known to stimulate intestinal motility. Since the indigenous microbiota of the ileum dominantly contains segmented filamentous bacteria (SFB), we tested the hypothesis that SFB are involved in increasing small intestinal transit (SIT). Five groups of mice were compared: germfree mice, mice mono-associated either with SFB or with Clostridium innocuum , SFB-free mice with a specified pathogen-free (SPF) microbiota and SFB-positive SPF mice. As a measure for intestinal transit, the distance travelled by a charcoal marker was determined 30 min after oral administration. We found a strong increase in SIT in both the mice mono-associated with SFB, and the SFB-positive SPF mice (P |
| Databáze: | OpenAIRE |
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