Long-term supplementation of dietary omega-6/omega-3 ratios alters bone marrow fatty acid and biomarkers of bone metabolism in growing rabbits
| Autor: | Abdulrahman S. Al-Khalifa, Fereidoon Shahidi, D.M. Al-Nouri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Growing rabbits
Prostaglandin E2 Dietary lipid Medicine (miscellaneous) Weanling Biology Acid phosphatase ACP Bone remodeling medicine Bone marrow TX341-641 Food science ω6 and ω3 PUFAs Alkaline phosphatase ALP chemistry.chemical_classification Nutrition and Dietetics Nutrition. Foods and food supply Fatty acid food and beverages Fish oil medicine.anatomical_structure chemistry Biochemistry Alkaline phosphatase lipids (amino acids peptides and proteins) Food Science Polyunsaturated fatty acid |
| Zdroj: | Journal of Functional Foods, Vol 4, Iss 3, Pp 584-593 (2012) |
| ISSN: | 1756-4646 |
| Popis: | The long-term effects of different dietary lipid sources with varying ratios of omega-6/omega-3 (ω6/ω3) polyunsaturated fatty acids (PUFAs) on the bone marrow fatty acid profile, ex vivo prostaglandin E 2 (PGE 2 ) release in bone, and plasma biomarkers of bone metabolism were evaluated in rabbits. Weanling male and female New Zealand white rabbits were randomly assigned to five groups and fed ad libitum on diets containing 70 g/kg of added oil for 100 days as follow: soy bean oil (SBO control), sesame oil (SO), fish oil (FO), DHA algae oil (DHA), and DHA and ARA algae oils (DHA/ARA). The dietary lipid treatments were formulated to provide the following ratios of ω6/ω3 fatty acids: 8.7 (SBO), 21.8 (SO), 0.4 (FO), 0.6 (DHA), and 0.7 (DHA/ARA). The bone marrow fatty acid profile of rabbits was significantly influenced by and reflected the dietary lipid treatments. Rabbits fed the FO diet had the highest ω3 PUFA concentration, and those fed the SBO diet were highest in ω6 PUFA. Ex vivo PGE 2 level declined progressively as the ω6/ω3 dietary ratio declined. Plasma alkaline phosphatase (ALP) activity was significantly higher in male and female rabbits fed the DHA/ARA diet compared with those fed the control, SO, FO, or DHA diets. These results demonstrated that the dietary ω6/ω3 ratio modulates bone PGE 2 production and plasma ALP activity in growing rabbits. In addition, the significant elevation in ALP activity in the DHA/ARA fed group proved that algae oils may be promising dietary sources for promoting bone formation during the growing stage. |
| Databáze: | OpenAIRE |
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