A chemical field guide to histone nonenzymatic modifications
Autor: | Igor Maksimovic, Yael David, Sarah Faulkner |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Acylation Molecular Conformation 010402 general chemistry 01 natural sciences Biochemistry Antioxidants Article Analytical Chemistry Epigenesis Genetic Histones 03 medical and health sciences chemistry.chemical_compound Polysaccharides Histone code Molecule Nucleosome Humans Epigenetics Binding Sites biology DNA Free Radical Scavengers Chromatin 0104 chemical sciences Histone Code 030104 developmental biology Histone chemistry Biophysics biology.protein Reactive Oxygen Species Protein Processing Post-Translational Function (biology) Protein Binding |
Zdroj: | Curr Opin Chem Biol |
ISSN: | 1879-0402 |
Popis: | Histone nonenzymatic covalent modifications (NECMs) have recently emerged as an understudied class of posttranslational modifications that regulate chromatin structure and function. These NECMs alter the surface topology of histone proteins, their interactions with DNA and chromatin regulators, as well as compete for modification sites with enzymatic posttranslational modifications. NECM formation depends on the chemical compatibility between a reactive molecule and its target site, in addition to their relative stoichiometries. Here we survey the chemical reactions and conditions that govern the addition of NECMs onto histones as a manual to guide the identification of new physiologically relevant chemical adducts. Characterizing NECMs on chromatin is critical to attain a comprehensive understanding of this new chapter of the so-called "histone code". |
Databáze: | OpenAIRE |
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