First description of Merkel Cell polyomavirus DNA detection in a patient with Stevens-Johnson syndrome
| Autor: | Marilena Granzotto, Natalia Maximova, Davide Zanon, Valentina Kiren, Manola Comar |
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| Přispěvatelé: | Maximova, N, Granzotto, M, Kiren, V, Zanon, D, Comar, Manola |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Mucocutaneous zone Merkel cell polyomavirus Biology DNA sequencing chemistry.chemical_compound Young Adult Virology medicine Cluster Analysis Humans Young adult Phylogeny Skin Merkel cell carcinoma Sequence Analysis DNA Amplicon Viral Load biology.organism_classification medicine.disease Infectious Diseases Blood chemistry Italy Stevens-Johnson Syndrome DNA Viral Female Viral load merkel cell virus Cidofovir |
| Popis: | Merkel Cell polyomavirus (MCPyV), a ubiquitous DNA tumor virus, has been found to be associated with Merkel cell carcinoma and chronic lymphocytic leukaemia while other associations are still being explored. MCPyV sequences have also been detected in normal tissues of tumor patients and in the blood of healthy donors. This report documents a new MCPyV association with the Stevens–Johnson syndrome, a rare immune-modulated mucocutaneous process particularly associated with specific drugs and infective agents. A high MCPyV viral load was detected simultaneously in fluid from skin lesions (2.0 × 104 copies/ml) and in matched blood (7.4 × 105 copies/ml) from a young adult patient after bone marrow transplant for a relapsed T-cell acute lymphatic leukaemia. MCPyV clearance concurred with the complete resolution of skin lesions after 5 days of cidofovir treatment. DNA sequencing classified the amplicons as the European/Italian MKL-1 strain. Given its ubiquitous nature, MCPyV could account for part of Stevens–Johnson syndrome idiopathic cases. J. Med. Virol. 85:918–923, 2013. © 2013 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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