The importance of trabecular hypertrophy in right ventricular adaptation to chronic pressure overload

Autor: Harm-Jan Bogaard, Sophie A. Dusoswa, Anton Vonk-Noordegraaf, Onno A. Spruijt, Taco Kind, J. Tim Marcus, Nico Westerhof, Mariëlle C. van de Veerdonk
Přispěvatelé: ICaR - Heartfailure and pulmonary arterial hypertension, Pulmonary medicine, Physics and medical technology, Physiology
Rok vydání: 2014
Předmět:
Adult
Male
medicine.medical_specialty
Cardiac Catheterization
Time Factors
medicine.medical_treatment
Hypertension
Pulmonary
Magnetic Resonance Imaging
Cine
Pulmonary Artery
Muscle hypertrophy
Predictive Value of Tests
Internal medicine
medicine.artery
medicine
Humans
Radiology
Nuclear Medicine and imaging
Arterial Pressure
Familial Primary Pulmonary Hypertension
Ventricular remodeling
Cardiac catheterization
Aged
Retrospective Studies
Pressure overload
medicine.diagnostic_test
Hypertrophy
Right Ventricular
Ventricular Remodeling
business.industry
Reproducibility of Results
Magnetic resonance imaging
Middle Aged
Papillary Muscles
medicine.disease
Adaptation
Physiological
Blood pressure
Predictive value of tests
Pulmonary artery
Cardiology
Ventricular Function
Right
Cardiology and Cardiovascular Medicine
business
Zdroj: International Journal of Cardiovascular Imaging, 30(2), 357-365. Springer Netherlands
van de Veerdonk, M C, Dusoswa, S A, Marcus, J T, Bogaard, H J, Spruijt, O A, Kind, T, Westerhof, N & Vonk-Noordegraaf, A 2014, ' The importance of trabecular hypertrophy in right ventricular adaptation to chronic pressure overload ', International Journal of Cardiovascular Imaging, vol. 30, no. 2, pp. 357-365 . https://doi.org/10.1007/s10554-013-0338-z
ISSN: 1569-5794
DOI: 10.1007/s10554-013-0338-z
Popis: To assess the contribution of right ventricular (RV) trabeculae and papillary muscles (TPM) to RV mass and volumes in controls and patients with pulmonary arterial hypertension (PAH). Furthermore, to evaluate whether TPM shows a similar response as the RV free wall (RVFW) to changes in pulmonary artery pressure (PAP) during follow-up. 50 patients underwent cardiac magnetic resonance (CMR) and right heart catheterization at baseline and after one-year follow-up. Furthermore 20 controls underwent CMR. RV masses were assessed with and without TPM. TPM constituted a larger proportion of total RV mass and RV end-diastolic volume (RVEDV) in PAH than in controls (Mass: 35 ± 7 vs. 25 ± 5 %; p < 0.001; RVEDV: 17 ± 6 vs. 12 ± 6 %; p = 0.003). TPM mass was related to the RVFW mass in patients (baseline: R = 0.65; p < 0.001; follow-up: R = 0.80; p < 0.001) and controls (R = 0.76; p < 0.001). In PAH and controls, exclusion of TPM from the assessment resulted in altered RV mass, volumes and function than when included (all p < 0.01). Changes in RV TPM mass (β = 0.44; p = 0.004) but not the changes in RVFW mass (p = 0.095) were independently related to changes in PAP during follow-up. RV TPM showed a larger contribution to total RV mass in PAH (~35 %) compared to controls (~25 %). Inclusion of TPM in the analyses significantly influenced the magnitude of the RV volumes and mass. Furthermore, TPM mass was stronger related to changes in PAP than RVFW mass. Our results implicate that TPM are important contributors to RV adaptation during pressure overload and cannot be neglected from the RV assessment.
Databáze: OpenAIRE
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