Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples
| Autor: | Luisa Lázaro, Dmitry Kapilushniy, Elena Shumskaya, Katya Rubia, Ana Cubillo, Philip Shaw, Marcus V. Zanetti, Anders M. Dale, Thomas Ethofer, Andreas Reif, Pieter J. Hoekstra, Mariam Zentis, Sarah Baumeister, Sara Lera-Miguel, Kerstin J. Plessen, Anastasia Solovieva, Catharina A. Hartman, João P.O.F.T. Guimarães, Tonya White, Hazel McCarthy, Thomas Frodl, Stephanie E. Novotny, Martine Hoogman, Mara Cercignani, Gustavo Sudre, Patrick de Zeeuw, Tiffany M. Chaim-Avancini, Ivanei E. Bramati, Yolanda Vives-Gilabert, J. Antoni Ramos-Quiroga, Jonna Kuntsi, Clare Kelly, Joel T. Nigg, Dirk J. Heslenfeld, Tinatin Gogberashvili, Mark A. Bellgrove, Susanne Walitza, Sarah Hohmann, Jan Haavik, Kaylita Chantiluke, Joseph Biederman, Marcel P. Zwiers, Maarten Mennes, Neil A. Harrison, Hanan El Marroun, Norbert Skokauskas, Mitul A. Mehta, Annette Conzelmann, Fernanda Tovar-Moll, Rosa Nicolau, Juan Carlos Soliva Vila, Mario Rodrigues Louzã, Ruth O'Gorman Tuura, Anastasia Christakou, Barbara Franke, Charles B Malpas, Theo G.M. van Erp, Eileen Oberwelland Weiss, Terry L. Jernigan, Alysa E. Doyle, Daniel Brandeis, David Coghill, L. Reneman, Tobias Banaschewski, Geraldo F. Busatto, Sarah Durston, Anouk Schrantee, Philip Asherson, Lena Schwarz, Georgii Karkashadze, Kerstin Konrad, Anatoly Anikin, Neda Jahanshad, Paul M. Thompson, Georg C. Ziegler, Paulo Mattos, Michael C. Stevens, Janita Bralten, Matt C. Gabel, Thomas Wolfers, Alasdair Vance, Leanne Tamm, Georg G. von Polier, Timothy J. Silk, Bernd Kardatzki, Jochen Seitz, Sabin Khadka, Ryan L. Muetzel, Marie F. Høvik, Damien A. Fair, Astri J. Lundervold, Eric Earl, Jeffery N. Epstein, Ramona Baur-Streubel, Paul Pauli, Yuliya N. Yoncheva, Jaap Oosterlaan, Gregor Kohls, Henning Tiemeier, Francisco X. Castellanos, Silvia Brem, Oscar Vilarroya, Pedro G.P. Rosa, Stephen V. Faraone, Klaus-Peter Lesch, Jan K. Buitelaar, Bob Oranje, Leyla Namazova-Baranova, A.A. Baranov, Andreas J. Fallgatter, Anna Calvo, Sara Ambrosino, Kathrin C. Zierhut, Yannis Paloyelis, Lizanne J. S. Schweren |
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| Přispěvatelé: | APH - Personalized Medicine, ANS - Compulsivity, Impulsivity & Attention, Radiology and Nuclear Medicine, General Paediatrics, ARD - Amsterdam Reproduction and Development, APH - Mental Health, Child and Adolescent Psychiatry / Psychology, Department of Psychology, Education and Child Studies, Erasmus MC other, Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Pediatric surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
SYMPTOMS CHILDREN Audiology physiopathology [Cerebral Cortex] 0302 clinical medicine CONNECTIVITY 130 000 Cognitive Neurology & Memory diagnostic imaging [Cerebral Cortex] physiopathology [Attention Deficit Disorder with Hyperactivity] PARTICIPANTS Young adult Child Child Behavior Checklist Cerebral Cortex education.field_of_study ATTENTION-DEFICIT/HYPERACTIVITY DISORDER Age Factors 220 Statistical Imaging Neuroscience Brain Middle Aged Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Cerebral cortex Child Preschool Female MRI Adult medicine.medical_specialty Adolescent DEFICIT HYPERACTIVITY DISORDER Population Neuroimaging behavioral disciplines and activities 150 000 MR Techniques in Brain Function Article Young Adult 03 medical and health sciences Sex Factors All institutes and research themes of the Radboud University Medical Center mental disorders medicine Journal Article Attention deficit hyperactivity disorder Humans ddc:610 education METAANALYSIS Psychiatric Status Rating Scales Fusiform gyrus Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7] business.industry ADULTS pathology [Attention Deficit Disorder with Hyperactivity] medicine.disease 030227 psychiatry SIZE Attention Deficit Disorder with Hyperactivity Case-Control Studies Endophenotype RC0321 diagnostic imaging [Attention Deficit Disorder with Hyperactivity] pathology [Cerebral Cortex] business 030217 neurology & neurosurgery |
| Zdroj: | American journal of psychiatry, 176(7), 531-542. American Psychiatric Association American Journal of Psychiatry, 176(7), 531-542. American Psychiatric Association American Journal of Psychiatry Am J Psychiatry American Journal of Psychiatry, 176(7), 531-542. AMER PSYCHIATRIC PUBLISHING, INC Hoogman, M, Muetzel, R, Guimaraes, J P, Shumskaya, E, Mennes, M, Zwiers, M P, Jahanshad, N, Sudre, G, Wolfers, T, Earl, E A, Soliva Vila, J C, Vives-Gilabert, Y, Khadka, S, Novotny, S E, Hartman, C A, Heslenfeld, D J, Schweren, L J S, Ambrosino, S, Oranje, B, De Zeeuw Oranje, P, Chaim-Avancini, T M, Rosa, P G P, Zanetti, M V, Malpas, C B, Kohls, G, Von Polier, G G, Seitz, J, Biederman, J, Doyle, A E, Dale, A M, van Erp, T G M, Epstein, J N, Jernigan, T L, Baur-Streubel, R, Ziegler, G C, Zierhut, K C, Schrantee, A, Høvik, M F, Lundervold, A J, Kelly, C, McCarthy, H, Skokauskas, N, O'Gorman Tuura, R L, Calvo, A, Lera-Miguel, S, Nicolau, R, Chantiluke, K C, Christakou, A, Vance, A, Cercignani, M, Gabel, M C, Asherson, P, Baumeister, S, Brandeis, D, Hohmann, S, Bramati, I E, Tovar-Moll, F, Fallgatter, A J, Kardatzki, B, Schwarz, L, Anikin, A, Baranov, A, Gogberashvili, T, Kapilushniy, D, Solovieva, A, El Marroun, H, White, T, Karkashadze, G, Namazova-Baranova, L, Ethofer, T, Mattos, P, Banaschewski, T, Coghill, D, Plessen, K J, Kuntsi, J, Mehta, M A, Paloyelis, Y, Harrison, N A, Bellgrove, M A, Silk, T J, Cubillo, A I, Rubia, K, Lazaro, L, Brem, S, Walitza, S, Frodl, T, Zentis, M, Castellanos, F X, Yoncheva, Y N, Haavik, J, Reneman, L, Conzelmann, A, Lesch, K P, Pauli, P, Reif, A, Tamm, L, Konrad, K, Oberwelland Weiss, E, Busatto, G F, Louza, M R, Durston, S, Hoekstra, P J, Oosterlaan, J, Stevens, M C, Ramos-Quiroga, J A, Vilarroya, O, Fair, D A, Nigg, J T, Thompson, P M, Buitelaar, J K, Faraone, S V, Shaw, P, Tiemeier, H, Bralten, J & Franke, B 2019, ' Brain Imaging of the Cortex in ADHD : A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples ', The American Journal of Psychiatry, vol. 176, no. 7, pp. 531-542 . https://doi.org/10.1176/appi.ajp.2019.18091033 American Journal of Psychiatry, 176, 7, pp. 531-542 American Journal of Psychiatry, 176(7), 531-542. American Psychiatric Publishing, Inc. The American journal of psychiatry 176(7), 531-542 (2019). doi:10.1176/appi.ajp.2019.18091033 American Journal of Psychiatry, 176, 531-542 American Journal of Psychiatry, 176(7), 531. American Psychiatric Association Hoogman, M, Muetzel, R, Guimaraes, J P, Shumskaya, E, Mennes, M, Zwiers, M P, Jahanshad, N, Sudre, G, Wolfers, T, Earl, E A, Soliva Vila, J C, Vives-Gilabert, Y, Khadka, S, Novotny, S E, Hartman, C A, Heslenfeld, D J, Schweren, L J S, Ambrosino, S, Oranje, B, de Zeeuw Oranje, P, Chaim-Avancini, T M, Rosa, P G P, Zanetti, M V, Malpas, C B, Kohls, G, von Polier, G G, Seitz, J, Biederman, J, Doyle, A E, Dale, A M, van Erp, T G M, Epstein, J N, Jernigan, T L, Baur-Streubel, R, Ziegler, G C, Zierhut, K C, Schrantee, A, Høvik, M F, Lundervold, A J, Kelly, C, McCarthy, H, Skokauskas, N, O'Gorman Tuura, R L, Calvo, A, Lera-Miguel, S, Nicolau, R, Chantiluke, K C, Christakou, A, Vance, A, Cercignani, M, Gabel, M C, Asherson, P, Baumeister, S, Brandeis, D, Hohmann, S, Bramati, I E, Tovar-Moll, F, Fallgatter, A J, Kardatzki, B, Schwarz, L, Anikin, A, Baranov, A, Gogberashvili, T, Kapilushniy, D, Solovieva, A, el Marroun, H, White, T, Karkashadze, G, Namazova-Baranova, L, Ethofer, T, Mattos, P, Banaschewski, T, Coghill, D, Plessen, K J, Kuntsi, J, Mehta, M A, Paloyelis, Y, Harrison, N A, Bellgrove, M A, Silk, T J, Cubillo, A I, Rubia, K, Lazaro, L, Brem, S, Walitza, S, Frodl, T, Zentis, M, Castellanos, F X, Yoncheva, Y N, Haavik, J, Reneman, L, Conzelmann, A, Lesch, K-P, Pauli, P, Reif, A, Tamm, L, Konrad, K, Oberwelland Weiss, E, Busatto, G F, Louza, M R, Durston, S, Hoekstra, P J, Oosterlaan, J, Stevens, M C, Ramos-Quiroga, J A, Vilarroya, O, Fair, D A, Nigg, J T, Thompson, P M, Buitelaar, J K, Faraone, S V, Shaw, P, Tiemeier, H, Bralten, J & Franke, B 2019, ' Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples ', American Journal of Psychiatry, vol. 176, no. 7, pp. 531-542 . https://doi.org/10.1176/appi.ajp.2019.18091033 |
| ISSN: | 0002-953X 1535-7228 |
| DOI: | 10.1176/appi.ajp.2019.18091033 |
| Popis: | Contains fulltext : 204879pub.pdf (Publisher’s version ) (Open Access) Contains fulltext : 204879pos.pdf (Author’s version postprint ) (Open Access) OBJECTIVE: Neuroimaging studies show structural alterations of various brain regions in children and adults with attention deficit hyperactivity disorder (ADHD), although nonreplications are frequent. The authors sought to identify cortical characteristics related to ADHD using large-scale studies. METHODS: Cortical thickness and surface area (based on the Desikan-Killiany atlas) were compared between case subjects with ADHD (N=2,246) and control subjects (N=1,934) for children, adolescents, and adults separately in ENIGMA-ADHD, a consortium of 36 centers. To assess familial effects on cortical measures, case subjects, unaffected siblings, and control subjects in the NeuroIMAGE study (N=506) were compared. Associations of the attention scale from the Child Behavior Checklist with cortical measures were determined in a pediatric population sample (Generation-R, N=2,707). RESULTS: In the ENIGMA-ADHD sample, lower surface area values were found in children with ADHD, mainly in frontal, cingulate, and temporal regions; the largest significant effect was for total surface area (Cohen's d=-0.21). Fusiform gyrus and temporal pole cortical thickness was also lower in children with ADHD. Neither surface area nor thickness differences were found in the adolescent or adult groups. Familial effects were seen for surface area in several regions. In an overlapping set of regions, surface area, but not thickness, was associated with attention problems in the Generation-R sample. CONCLUSIONS: Subtle differences in cortical surface area are widespread in children but not adolescents and adults with ADHD, confirming involvement of the frontal cortex and highlighting regions deserving further attention. Notably, the alterations behave like endophenotypes in families and are linked to ADHD symptoms in the population, extending evidence that ADHD behaves as a continuous trait in the population. Future longitudinal studies should clarify individual lifespan trajectories that lead to nonsignificant findings in adolescent and adult groups despite the presence of an ADHD diagnosis. |
| Databáze: | OpenAIRE |
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