| Autor: |
David L. Selwood, Basil Hartzoulakis, Jeff Labadie, Sharon Rossiter, Lee Stanyer, Grant Wishart, Chi Kit Woo |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Journal of combinatorial chemistry. 6(3) |
| ISSN: |
1520-4766 |
| Popis: |
A N-derivatized 3-dimethylaminopropyloxypyrazole library was prepared using solution-phase parallel synthesis. The library was designed using physicochemical constraints designed to remove non-membrane-permeable molecules. Cupric acetate-mediated N-arylation with aryl boronic acids proceeded regioselectively to form the N-2-substituted derivatives. The presence of the 3-dimethylaminopropyloxy group was found to completely control the regioselectivity of the arylation. Presence of a dimethylaminoethyloxy or dimethylaminobutyloxy group gave a lesser degree of regioselectivity. The scope of the method as applied to library synthesis is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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