Green MIP-202(Zr) Catalyst: Degradation and Thermally Robust Biomimetic Sensing of Nerve Agents
| Autor: | Samar S. Sandhu, Yugender Goud Kotagiri, P. U. Ashvin Iresh Fernando I., Mark Kalaj, Nicholas Tostado, Hazhir Teymourian, Erik M. Alberts, Travis L. Thornell, Glen R. Jenness, Steven P. Harvey, Seth M. Cohen, Lee C. Moores, Joseph Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Isoflurophate
Potentiometric titration chemistry.chemical_element Biochemistry Catalysis Fluorides Wearable Electronic Devices chemistry.chemical_compound Colloid and Surface Chemistry Biomimetic Materials Limit of Detection medicine Metal-Organic Frameworks Nerve agent Zirconium Extraction (chemistry) Green Chemistry Technology Electrochemical Techniques General Chemistry chemistry Chemical engineering Electrode Degradation (geology) Nerve Agents Fluoride medicine.drug |
| Zdroj: | Journal of the American Chemical Society. 143:18261-18271 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | Rapid and robust sensing of nerve agent (NA) threats is necessary for real-time field detection to facilitate timely countermeasures. Unlike conventional phosphotriesterases employed for biocatalytic NA detection, this work describes the use of a new, green, thermally stable, and biocompatible zirconium metal-organic framework (Zr-MOF) catalyst, MIP-202(Zr). The biomimetic Zr-MOF-based catalytic NA recognition layer was coupled with a solid-contact fluoride ion-selective electrode (F-ISE) transducer, for potentiometric detection of diisopropylfluorophosphate (DFP), a F-containing G-type NA simulant. Catalytic DFP degradation by MIP-202(Zr) was evaluated and compared to the established UiO-66-NH2 catalyst. The efficient catalytic DFP degradation with MIP-202(Zr) at near-neutral pH was validated by 31P NMR and FT-IR spectroscopy and potentiometric F-ISE and pH-ISE measurements. Activation of MIP-202(Zr) using Soxhlet extraction improved the DFP conversion rate and afforded a 2.64-fold improvement in total percent conversion over UiO-66-NH2. The exceptional thermal and storage stability of the MIP-202/F-ISE sensor paves the way toward remote/wearable field detection of G-type NAs in real-world environments. Overall, the green, sustainable, highly scalable, and biocompatible nature of MIP-202(Zr) suggests the unexploited scope of such MOF catalysts for on-body sensing applications toward rapid on-site detection and detoxification of NA threats. |
| Databáze: | OpenAIRE |
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